Real Francisco Gómez, Svanes Cecilie, Omenaas Ernst Reidar, Antò Josep Maria, Plana Estel, Jarvis Deborah, Janson Christer, Neukirch Françoise, Zemp Elisabeth, Dratva Julia, Wjst Matthias, Svanes Knut, Leynaert Bénédicte, Sunyer Jordi
Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway.
J Allergy Clin Immunol. 2008 Jan;121(1):72-80.e3. doi: 10.1016/j.jaci.2007.08.057. Epub 2007 Oct 29.
There is limited information on potential changes in respiratory health when women enter the menopausal transition.
We sought to investigate whether the menopausal transition is related to lung function and asthma and whether body mass index (BMI) modifies associations.
Four thousand two hundred fifty-nine women from 21 centers (ECRHS II, 2002) responded to a questionnaire concerning women's health. Women aged 45 to 56 years not using exogenous sex hormones (n = 1274) were included in the present analysis. Lung function measurements (n = 1120) and serum markers of hormonal status (follicle-stimulating hormone, luteinizing hormone, and estradiol; n = 710) were available. Logistic and linear regression analyses were adjusted for BMI, age, years of education, smoking status, center, and height.
Women not menstruating for the last 6 months (n = 432, 34%) had significantly lower FEV(1) values (-120 mL [95% CI, -177 to -63]), lower forced vital capacity values (-115 mL [95% CI, -181 to -50]), and more respiratory symptoms (odds ratio [OR], 1.82 [95% CI, 1.27-2.61]) than those menstruating regularly. Results were similar when restricting analyses to those who never smoked. Associations were significantly stronger in women with BMIs of less than 23 kg/m(2) (respiratory symptoms: OR, 4.07 [95% CI, 1.88-8.80]; FEV(1) adjusted difference: -166 [95% CI, -263 to -70]) than in women with BMIs of 23 to 28 kg/m(2) (respiratory symptoms: OR, 1.10 [95% CI, 0.61-1.97], P(interaction): .04; FEV(1) adjusted difference, -54 [95% CI, -151 to 43], P(interaction) = .06).
Menopause is associated with lower lung function and more respiratory symptoms, especially among lean women.
关于女性进入围绝经期时呼吸健康的潜在变化，相关信息有限。
我们试图研究围绝经期是否与肺功能和哮喘有关，以及体重指数（BMI）是否会改变这种关联。
来自21个中心的4259名女性（欧洲社区呼吸健康调查II，2002年）回答了一份关于女性健康的问卷。本分析纳入了45至56岁未使用外源性性激素的女性（n = 1274）。可获得肺功能测量值（n = 1120）和激素状态的血清标志物（促卵泡激素、促黄体生成素和雌二醇；n = 710）。逻辑回归和线性回归分析对BMI、年龄、受教育年限、吸烟状况、中心和身高进行了校正。
过去6个月未月经的女性（n = 432，34%）的第一秒用力呼气容积（FEV₁）值显著更低（-120 mL [95% CI，-177至-�3]），用力肺活量值更低（-115 mL [95% CI，-181至-50]），且呼吸症状更多（比值比[OR]，1.82 [95% CI，1.27 - 2.61]），高于月经规律的女性。将分析限制在从不吸烟的女性中时，结果相似。BMI小于23 kg/m²的女性中关联显著更强（呼吸症状：OR，4.07 [95% CI，1.88 - 8.80]；FEV₁校正差异：-166 [95% CI，-263至-70]），高于BMI为23至28 kg/m²的女性（呼吸症状：OR，1.10 [95% CI，0.61 - 1.97]，交互作用P值：.04；FEV₁校正差异，-54 [95% CI，-151至43]，交互作用P值 =.06）。
绝经与较低的肺功能和更多的呼吸症状相关，尤其是在瘦女性中。
