Department of Gynecology and Obstetrics, Haukeland University Hospital, 5021 Bergen, Norway.
Am J Respir Crit Care Med. 2011 Jan 1;183(1):8-14. doi: 10.1164/rccm.200912-1886OC. Epub 2010 Aug 23.
hormonal and metabolic status appears to influence lung health in women, and there are findings suggesting that early menarche may be related to asthma, cardiovascular disease, diabetes, and breast cancer.
this study investigates whether age at menarche is related to adult lung function and asthma.
among participants in the European Community Respiratory Health Survey II, 3,354 women aged 27-57 years from random population samples in 21 centers responded to a questionnaire concerning women's health (1998-2002). Of these women, 2,873 had lung function measurements, 2,136 had measurements of bronchial hyperreactivity, and 2,743 had IgE measurements. Logistic, linear, and negative binomial regression analyses included adjustment for age, height, body mass index, education, smoking, family size, and center.
FEV(1) and FVC were lower and asthma was more common in women with early menarche. Women reporting menarche at age 10 years or less, as compared with women with menarche at age 13 years (reference category), had lower FEV(1) (adjusted difference, -113 ml; 95% confidence interval [CI], -196 to -33 ml) and FVC (-126 ml; 95% CI, -223 to -28 ml); also lower FEV(1) expressed as a percentage of the predicted value (-3.28%; 95% CI, -6.25 to -0.30%) and FVC expressed as a percentage of the predicted value (-3.63%; 95% CI, -6.64 to -0.62%). Women with early menarche more often had asthma symptoms (odds ratio, 1.80; 95% CI, 1.09-2.97), asthma with bronchial hyperreactivity (odds ratio, 2.79; 95% CI, 1.06-7.34), and higher asthma symptom score (mean ratio, 1.58; 95% CI, 1.12-2.21).
women with early menarche had lower lung function and more asthma in adulthood. This supports a role for metabolic and hormonal factors in women's respiratory health.
荷尔蒙和代谢状态似乎会影响女性的肺部健康，有研究结果表明，初潮较早可能与哮喘、心血管疾病、糖尿病和乳腺癌有关。
本研究旨在调查初潮年龄是否与成人肺功能和哮喘有关。
在欧洲社区呼吸健康调查 II 中，来自 21 个中心随机人群样本的 3354 名 27-57 岁的女性回答了有关女性健康的问卷（1998-2002 年）。在这些女性中，有 2873 人进行了肺功能测量，2136 人进行了支气管高反应性测量，2743 人进行了 IgE 测量。使用逻辑回归、线性回归和负二项回归分析，调整了年龄、身高、体重指数、教育程度、吸烟、家庭规模和中心因素。
初潮较早的女性的 FEV1 和 FVC 较低，哮喘更为常见。与初潮年龄为 13 岁（参考类别）的女性相比，初潮年龄为 10 岁或更早的女性的 FEV1 更低（调整差异为-113ml；95%置信区间为-196 至-33ml）和 FVC 更低（-126ml；95%置信区间为-223 至-28ml）；FEV1 占预计值的百分比也较低（-3.28%；95%置信区间为-6.25 至-0.30%），FVC 占预计值的百分比也较低（-3.63%；95%置信区间为-6.64 至-0.62%）。初潮较早的女性更常出现哮喘症状（比值比，1.80；95%置信区间为 1.09-2.97）、哮喘伴支气管高反应性（比值比，2.79；95%置信区间为 1.06-7.34）和更高的哮喘症状评分（平均比值，1.58；95%置信区间为 1.12-2.21）。
初潮较早的女性在成年后肺功能较低，且哮喘更为常见。这支持代谢和荷尔蒙因素在女性呼吸系统健康中的作用。
