Milton S, Murtola M, Sandbrink J, Yeheskiely E, Strömberg R
Department of Biosciences & Nutrition, Novum, Karolinska Institutet, S-14157 Huddinge, Sweden.
Nucleic Acids Symp Ser (Oxf). 2007(51):61. doi: 10.1093/nass/nrm031.
Presented is our most recent work on synthesis and properties of oligonucleotide analogues and conjugates These include 2'-carbamoylmethyl derivatives, peptideoligonucleotide conjugates and conjugates made to combine Watson-Crick and non-Watson-Crick interactions as well as conjugates with RNA-cleaving groups. Recent results on cleavage of RNA by artificial nucleases, is also presented.
这里展示的是我们关于寡核苷酸类似物和缀合物的合成及性质的最新研究成果。这些包括2'-氨甲酰甲基衍生物、肽-寡核苷酸缀合物、结合了沃森-克里克和非沃森-克里克相互作用的缀合物以及带有RNA切割基团的缀合物。还展示了人工核酸酶切割RNA的最新结果。
