Ito K, Sano Y, Horiuchi Y, Matuhasi T, Woodfield D G
Jpn J Exp Med. 1976 Feb;46(1):79-85.
Levels of IgE as well as specific IgE antibodies to ascaris and mite have been studied in two groups in Papua New Guinea (PNG), patients with primary liver carcinoma (PLC) and normal blood donors, and in two groups in Japan, normal subjects and asthmatic patients. A radioallergosorbent test was used to measure IgE antibodies to ascaris and mite antigens. Much higher levels of IgE were found in the Papua New Guinean subjects than the normal Japanese subjects. Also levels of IgE antibodies to ascaris were much higher in Papua New Guineans than in the Japanese subjects. Though similar results were observed in IgE antibodies to mite, difference between normal Papua New Guineans and normal Japanese was small, whereas difference between the patients with PLC in PNG and the normal Japanese subjects was very large. Highest levels of IgE antibodies to mite were detected in Japanese with asthma. No correlations were observed among IgE levels, levels of IgE antibodies to ascaris and levels of IgE antibodies to mite. It is concluded that both ascaris and mite IgE antibodies contribute the very high levels of IgE seen in Papua New Guineans, but many other factors may be operative.
在巴布亚新几内亚（PNG）的两组人群（原发性肝癌患者和正常献血者）以及日本的两组人群（正常受试者和哮喘患者）中，研究了IgE水平以及针对蛔虫和螨虫的特异性IgE抗体。采用放射变应原吸附试验来检测针对蛔虫和螨虫抗原的IgE抗体。结果发现，巴布亚新几内亚受试者的IgE水平远高于正常日本受试者。而且，巴布亚新几内亚人针对蛔虫的IgE抗体水平也远高于日本受试者。虽然针对螨虫的IgE抗体也观察到了类似结果，但正常巴布亚新几内亚人和正常日本人之间的差异较小，而PNG的原发性肝癌患者与正常日本受试者之间的差异非常大。在日本哮喘患者中检测到针对螨虫的IgE抗体水平最高。未观察到IgE水平、针对蛔虫的IgE抗体水平和针对螨虫的IgE抗体水平之间存在相关性。得出的结论是，蛔虫和螨虫的IgE抗体都导致了巴布亚新几内亚人出现非常高的IgE水平，但可能还有许多其他因素在起作用。
