Médigue Claudine, Moszer Ivan
CNRS UMR8030, Génomique Métabolique, 2 rue Gaston Crémieux, 91057 Evry Cedex, France.
Res Microbiol. 2007 Dec;158(10):724-36. doi: 10.1016/j.resmic.2007.09.009. Epub 2007 Oct 6.
The multitude of bacterial genome sequences being determined has opened up a new field of research, that of comparative genomics. One role of bioinformatics is to assist biologists in the extraction of biological knowledge from this data flood. Software designed for the analysis and functional annotation of a single genome have, in consequence, evolved towards comparative genomics tools, bringing together the information contained in numerous genomes simultaneously. This paper reviews advances in the development of bacterial annotation and comparative analysis tools, and progress in the design of novel database structures for the integration of heterogeneous biological information.
大量正在测定的细菌基因组序列开启了一个新的研究领域，即比较基因组学。生物信息学的一个作用是帮助生物学家从这一数据洪流中提取生物学知识。因此，为单个基因组的分析和功能注释而设计的软件已朝着比较基因组学工具的方向发展，能够同时整合众多基因组中包含的信息。本文综述了细菌注释和比较分析工具开发方面的进展，以及用于整合异构生物信息的新型数据库结构设计方面的进展。
