Haouem Samir, Najjar Mohamed Fathel, El Hani Abdelhamid, Sakly Rachid
Departement de Physiologie, Faculté de Médecine de Monastir, 5019 Monastir, Tunisia.
Exp Toxicol Pathol. 2008 Mar;59(5):307-11. doi: 10.1016/j.etp.2007.10.002. Epub 2007 Nov 26.
The aim of this study was to examine the accumulation of cadmium (Cd) incorporated in radish bulb and its effects on testes function in male rats. Control animals were given diet containing ordinary radish bulb for 4, 8 and 12 weeks, while contaminated animals were given diet containing Cd-polluted radish bulb (1.1 microg Cd/g of diet) for the same periods as in controls. At each time point, rats were killed and plasma was collected, and the testes and epididymides were removed. The findings indicated that the ratio of testes weight to body weight of contaminated rats was identical to that of control rats. Cd concentration in the testes significantly and gradually increased from the 4th to the 12th week of treatment. After 12 weeks of treatment, plasma testosterone levels significantly increased, while epididymal sperm concentration significantly decreased in contaminated rats as compared to correspondent controls.
本研究的目的是检测萝卜根中镉（Cd）的蓄积情况及其对雄性大鼠睾丸功能的影响。对照组动物喂食含普通萝卜根的饲料4周、8周和12周，而污染组动物在相同时间段内喂食含镉污染萝卜根的饲料（每克饲料含1.1微克镉）。在每个时间点，处死大鼠并采集血浆，同时取出睾丸和附睾。结果表明，污染组大鼠睾丸重量与体重之比与对照组大鼠相同。在治疗的第4周~第12周，睾丸中的镉浓度显著且逐渐升高。治疗12周后，与相应对照组相比，污染组大鼠血浆睾酮水平显著升高，而附睾精子浓度显著降低。
