Iaquinta Phillip J, Lees Jacqueline A
Center for Cancer Research, Massachusetts Institute of Technology, E17-517B, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
Curr Opin Cell Biol. 2007 Dec;19(6):649-57. doi: 10.1016/j.ceb.2007.10.006. Epub 2007 Nov 26.
The E2F transcription factors are critical regulators of genes required for appropriate progression through the cell cycle, and in special circumstances they can also promote the expression of another class of genes that function in the apoptotic program. Since E2Fs can initiate both cell proliferation and cell death, it is not surprising that the pro-apoptotic capacity of these proteins is subject to complex regulation. Recent study has expanded our knowledge of the factors influencing E2F-induced apoptosis as well as downstream targets of E2F in this process.
E2F转录因子是细胞周期正常进程所需基因的关键调节因子，在特殊情况下，它们还能促进另一类在凋亡程序中起作用的基因的表达。由于E2F既能启动细胞增殖又能引发细胞死亡，因此这些蛋白质的促凋亡能力受到复杂调控也就不足为奇了。最近的研究扩展了我们对影响E2F诱导凋亡的因素以及该过程中E2F下游靶点的认识。
