Affiliated Zhejiang Hospital, Zhejiang University School of Medicine, Hangzhou, 310030, China.
College of Life Science, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
Virol J. 2023 Nov 1;20(1):250. doi: 10.1186/s12985-023-02203-y.
The DNA damage response (DDR) is a signaling cascade that is triggered by DNA damage, involving the halting of cell cycle progression and repair. It is a key event leading to senescence, which is characterized by irreversible cell cycle arrest and the senescence-associated secretory phenotype (SASP) that includes the expression of inflammatory cytokines. Human cytomegalovirus (HCMV) is a ubiquitous pathogen that plays an important role in the senescence process. It has been established that DDR is necessary for HCMV to replicate effectively. This paper reviews the relationship between DDR, cellular senescence, and HCMV, providing new sights for virus-induced senescence (VIS).
DNA 损伤反应 (DDR) 是一种由 DNA 损伤触发的信号级联反应，涉及细胞周期进程的停滞和修复。它是导致衰老的关键事件，衰老的特征是细胞周期不可逆停滞和衰老相关分泌表型 (SASP)，包括炎症细胞因子的表达。人类巨细胞病毒 (HCMV) 是一种普遍存在的病原体，在衰老过程中发挥着重要作用。已经确定 DDR 是 HCMV 有效复制所必需的。本文综述了 DDR、细胞衰老与 HCMV 之间的关系，为病毒诱导的衰老 (VIS) 提供了新的视角。
