Guerin S R, MacNiochaill R, O'Reilly P, O'Byrne J, Kelly D J
Trinity Centre for Bioengineering, Department of Mechanical and Manufacturing Engineering, Trinity College, Dublin, Ireland.
Biomed Mater Eng. 2007;17(6):379-86.
Hydrogen peroxide has been used for decades as an effervescent haemostatic agent in arthroplasty. Recently it has been shown to adversely affect the material properties of PMMA. We aim to assess whether any such deleterious effects are demonstrated in an experimental model which mimics the clinical use of hydrogen peroxide. Matched pairs of cancellous bone samples were treated with a swab soaked in either saline or a 3% solution of hydrogen peroxide, prior to manufacture of cement-bone constructs using Palacos or Simplex cement. Thirty pairs were then compared by subjecting them to a torsional shear force until failure and a further thirty pairs were tested to failure in tension. There was no significant difference between the mean torques to failure for the Palacos-peroxide group versus the Palacos-saline group, or the Simplex-peroxide versus the Simplex-saline group (p=0.31 and 0.71 respectively). Similarly there was no significant difference between the mean tension loads to failure for the Palacos-peroxide group versus the Palacos-saline group, and the Simplex-peroxide versus the Simplex-saline group (p=0.79 and 0.23 respectively). We conclude that the use of hydrogen peroxide as an effervescent haemostatic agent has no detrimental effect on the mechanical integrity of the bone-cement interface when compared to normal saline.
几十年来，过氧化氢一直被用作关节置换术中的发泡止血剂。最近有研究表明，它会对聚甲基丙烯酸甲酯（PMMA）的材料性能产生不利影响。我们旨在评估在模拟过氧化氢临床使用的实验模型中是否会出现此类有害影响。在使用Palacos或Simplex骨水泥制造骨水泥构建体之前，将配对的松质骨样本用浸泡在生理盐水或3%过氧化氢溶液中的拭子进行处理。然后，对30对样本施加扭转剪切力直至破坏，并对另外30对样本进行拉伸破坏测试。Palacos-过氧化氢组与Palacos-生理盐水组之间，以及Simplex-过氧化氢组与Simplex-生理盐水组之间的平均破坏扭矩没有显著差异（分别为p = 0.31和0.71）。同样，Palacos-过氧化氢组与Palacos-生理盐水组之间，以及Simplex-过氧化氢组与Simplex-生理盐水组之间的平均拉伸破坏载荷也没有显著差异（分别为p = 0.79和0.23）。我们得出结论，与生理盐水相比，使用过氧化氢作为发泡止血剂对骨水泥界面的机械完整性没有不利影响。
