Fang Annette S, Miao Xiusheng, Tidswell Peter W, Towle Marc H, Goetzinger Wolfgang K, Kyranos James N
ArQule, Inc., Woburn, MA, USA.
Mass Spectrom Rev. 2008 Jan-Feb;27(1):20-34. doi: 10.1002/mas.20153.
In this Section, we review the applications of mass spectrometry for the analysis and purification of new chemical entities (NCEs) for pharmaceutical discovery. Since the speed of synthesis of NCEs has dramatically increased over the last few years, new high throughput analytical techniques have been developed to keep pace with the synthetic developments. In this Section, we review both novel, as well as modifications of commonly used mass spectrometry techniques that have helped increase the speed of the analytical process. Part of the review is devoted to the purification of NCEs, which has undergone significant development in recent years, and the close integral association between characterization and purification to drive high throughput operations. At the end of the Section, we review potential future directions based on promising and exciting new developments.
在本节中，我们将回顾质谱法在药物研发中用于分析和纯化新化学实体（NCEs）的应用。由于在过去几年中NCEs的合成速度大幅提高，因此已开发出新的高通量分析技术以跟上合成技术的发展。在本节中，我们将回顾有助于提高分析过程速度的新型质谱技术以及常用质谱技术的改进。综述的一部分内容致力于NCEs的纯化，近年来其纯化技术有了显著发展，以及表征与纯化之间紧密的整体关联以推动高通量操作。在本节末尾，我们将基于有前景且令人兴奋的新进展来回顾潜在的未来发展方向。
