来自阿普里马克马缨丹的新型萜类化合物作为寄生虫利什曼原虫的多药耐药逆转剂

New terpenoids from Maytenus apurimacensis as MDR reversal agents in the parasite Leishmania.

作者信息

Delgado-Méndez Paulino, Herrera Nora, Chávez Haydee, Estévez-Braun Ana, Ravelo Angel G, Cortes Fernando, Castanys Santiago, Gamarro Francisco

机构信息

Instituto Universitario de Bio-Orgánica 'Antonio González', Universidad de La Laguna. Avda. Astrofísico Fco. Sánchez No 2, 38206, La Laguna, Tenerife, Spain.

出版信息

Bioorg Med Chem. 2008 Feb 1;16(3):1425-30. doi: 10.1016/j.bmc.2007.10.071. Epub 2007 Nov 26.

DOI:10.1016/j.bmc.2007.10.071

PMID:18035546

Abstract

Two new sesquiterpenes (1-2) and one new lupane triterpene (3) have been isolated from the roots of Maytenus apurimacensis. The novel beta-dihydroagarofurans are the first sesquiterpenes with a basic polyhydroxy skeleton of 15-deoxyalatol and 4,15-dideoxyalatol that show high MDR reversing activity in the protozoan parasite Leishmania tropica.

摘要

从阿普里马克美登木（Maytenus apurimacensis）的根部分离出了两种新的倍半萜（1-2）和一种新的羽扇豆烷三萜（3）。这些新型的β-二氢agarofurans是首批具有15-脱氧alatol和4,15-二脱氧alatol基本多羟基骨架的倍半萜，它们在原生动物寄生虫热带利什曼原虫（Leishmania tropica）中表现出高多药耐药逆转活性。