合成柠檬烯衍生物及其对利什曼原虫和锥虫的体外活性。
Synthesis and in vitro activity of limonene derivatives against Leishmania and Trypanosoma.
机构信息
Lab. de Síntese Orgânica Medicinal (LaSOM), Faculdade de Farmácia, UFRGS, Avenida Ipiranga, 2752, sala 705, 90610-000 Porto Alegre, RS, Brazil.
出版信息
Eur J Med Chem. 2010 Apr;45(4):1524-8. doi: 10.1016/j.ejmech.2009.12.061. Epub 2010 Jan 14.
PMID:20116908
Abstract
The synthesis and in vitro activity of R(+)-Limonene derivatives against Leishmania and Trypanosoma cruzi strains are reported. Seven compounds have shown better in vitro activity against Leishmania (V.)braziliensis than the standard drug pentamidine. Additionally, we have identified two promising new anti-T. cruzi limonene derivatives.
摘要
报道了 R(+)-柠檬烯衍生物的合成及其对利什曼原虫和克氏锥虫株的体外活性。有 7 种化合物对巴西利什曼原虫（V.）的体外活性优于标准药物喷他脒。此外，我们还鉴定了两种有前途的新型抗克氏锥虫柠檬烯衍生物。
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