Aghajanova L, Hamilton A E, Giudice L C
Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, CA 94143-0132, USA.
Semin Cell Dev Biol. 2008 Apr;19(2):204-11. doi: 10.1016/j.semcdb.2007.10.008. Epub 2007 Oct 22.
Embryonic implantation is a dynamic process of paracrine interactions between the maternal compartment and the conceptus and involves a receptive endometrium and a developmentally competent blastocyst. Herein, we review histology, clinical approaches, and the promise of transcriptomics in elucidating mechanisms underlying implantation and development of biomarkers of uterine receptivity-with an eye to diagnose and treat implantation-based disorders of miscarriage, fetal growth restriction, pre-eclampsia, and infertility.
胚胎着床是母体与孕体之间旁分泌相互作用的动态过程，涉及到具有接受性的子宫内膜和发育能力良好的囊胚。在此，我们回顾了组织学、临床方法以及转录组学在阐明着床机制和子宫接受性生物标志物方面的前景，旨在诊断和治疗基于着床的流产、胎儿生长受限、先兆子痫和不孕症等疾病。
