子宫对人类胚胎着床的接受性：组织学、生物标志物和转录组学。
Uterine receptivity to human embryonic implantation: histology, biomarkers, and transcriptomics.
作者信息
Aghajanova L, Hamilton A E, Giudice L C
机构信息
Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, CA 94143-0132, USA.
出版信息
Semin Cell Dev Biol. 2008 Apr;19(2):204-11. doi: 10.1016/j.semcdb.2007.10.008. Epub 2007 Oct 22.
Abstract
Embryonic implantation is a dynamic process of paracrine interactions between the maternal compartment and the conceptus and involves a receptive endometrium and a developmentally competent blastocyst. Herein, we review histology, clinical approaches, and the promise of transcriptomics in elucidating mechanisms underlying implantation and development of biomarkers of uterine receptivity-with an eye to diagnose and treat implantation-based disorders of miscarriage, fetal growth restriction, pre-eclampsia, and infertility.
摘要
胚胎着床是母体与孕体之间旁分泌相互作用的动态过程，涉及到具有接受性的子宫内膜和发育能力良好的囊胚。在此，我们回顾了组织学、临床方法以及转录组学在阐明着床机制和子宫接受性生物标志物方面的前景，旨在诊断和治疗基于着床的流产、胎儿生长受限、先兆子痫和不孕症等疾病。
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本文引用的文献
1
Reprint of: Dating the Endometrial Biopsy.
Fertil Steril. 2019 Oct;112(4 Suppl1):e93-e115. doi: 10.1016/j.fertnstert.2019.08.079.
2
Differentially expressed genes implicated in unexplained recurrent spontaneous abortion.
Int J Biochem Cell Biol. 2007;39(12):2265-77. doi: 10.1016/j.biocel.2007.06.012. Epub 2007 Jun 30.
3
Human implantation: the last barrier in assisted reproduction technologies?
Reprod Biomed Online. 2006 Dec;13(6):887-904. doi: 10.1016/s1472-6483(10)61039-5.
4
Application of functional genomics to primate endometrium: insights into biological processes.
Reprod Biol Endocrinol. 2006;4 Suppl 1(Suppl 1):S4. doi: 10.1186/1477-7827-4-S1-S4.
5
Deficient expression of monoamine oxidase A in the endometrium is associated with implantation failure in women participating as recipients in oocyte donation.
Mol Hum Reprod. 2006 Dec;12(12):749-54. doi: 10.1093/molehr/gal082. Epub 2006 Oct 4.
6
Expression and activation of mitogen-activated protein kinase in the human endometrium during the menstrual cycle.
Am J Obstet Gynecol. 2006 Nov;195(5):1343-50. doi: 10.1016/j.ajog.2006.05.014. Epub 2006 Jun 21.
7
Glycodelin is present in pinopodes of receptive-phase human endometrium and is associated with down-regulation of progesterone receptor B.
Fertil Steril. 2006 Jun;85(6):1803-11. doi: 10.1016/j.fertnstert.2005.12.018.
8
Impaired expression of endometrial differentiation markers and complement regulatory proteins in patients with recurrent pregnancy loss associated with antiphospholipid syndrome.
Mol Hum Reprod. 2006 Jul;12(7):435-42. doi: 10.1093/molehr/gal048. Epub 2006 May 30.
9
Dickkopf-1, an inhibitor of Wnt signaling, is regulated by progesterone in human endometrial stromal cells.
J Clin Endocrinol Metab. 2006 Apr;91(4):1453-61. doi: 10.1210/jc.2005-0769. Epub 2006 Jan 31.
10
[Is glycodelin an important marker of endometrial receptivity?].
Ginekol Pol. 2005 Oct;76(10):770-81.
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