Teeratakulpisarn Jamaree, Ekalaksananan Tipaya, Pientong Chamsai, Limwattananon Chulaporn
Department of Pediatrics, Faculty of Medicine, Khon Kaen University, Thailand.
Asian Pac J Allergy Immunol. 2007 Jun-Sep;25(2-3):139-45.
This study was conducted to detect human metapneumovirus (hMPV) and respiratory syncytial virus (RSV) in young children hospitalized with acute bronchiolitis, using reverse transcriptase polymerase chain reaction (RT-PCR). Nasopharyngeal secretions were collected from 170 children between 1 and 24 months of age admitted to two tertiary hospitals in northeastern Thailand, between 2002 and 2004. Acute bronchiolitis was defined as the first episode of wheezing associated with tachypnea, increased respiratory effort and an upper respiratory tract infection. Two-thirds (115/170) were positive for viral etiologies: 64.7% RSV (110/170) and 3.5% hMPV (6/170). One patient had a dual infection. hMPV was detected between August and November, while RSV was prevalent from July through March. The clinical manifestations among the 6 hMPV, RSV and non-RSV-infected children were similar. RSV was the leading cause of acute bronchiolitis in young children and hMPV had a low prevalence in northeastern Thailand.
本研究旨在利用逆转录聚合酶链反应（RT-PCR）检测因急性细支气管炎住院的幼儿中的人偏肺病毒（hMPV）和呼吸道合胞病毒（RSV）。2002年至2004年间，从泰国东北部两家三级医院收治的170名1至24个月大的儿童中采集了鼻咽分泌物。急性细支气管炎被定义为与呼吸急促、呼吸费力增加和上呼吸道感染相关的首次喘息发作。三分之二（115/170）的患儿病毒病因检测呈阳性：64.7%为RSV（110/170），3.5%为hMPV（6/170）。1名患儿为双重感染。hMPV在8月至11月间被检测到，而RSV在7月至次年3月流行。6名感染hMPV、RSV和未感染RSV的儿童的临床表现相似。RSV是幼儿急性细支气管炎的主要病因，hMPV在泰国东北部的患病率较低。
