Tu M, Cha Z-G, Zhao J-H, Feng B-H, Zhou C-R
Jinan University, Department of Material Science and Engineering, College of Science and Engineering, Guangzhou, People's Republic of China.
IET Nanobiotechnol. 2007 Dec;1(6):87-93. doi: 10.1049/iet-nbt:20070015.
A series of polymer/cholesteryl liquid crystal (LC) composite membranes were prepared. Polyurethane and polyvinyl chloride, as a substrate, were blended with cholesteryl tetraethylene glycol carbonate to form composite membranes in an electric field under normal conditions. The blood compatibility of composite materials was identified by the dynamic blood-clotting test, haemolysis ratio measurement, platelet adhesion and SEM observation. The results showed that the content of LC, the ordered extent of LC domains embedded in composite materials and the type of substrate have greater effects on the blood compatibility of polymer/LC composite materials. When the LC domains were properly oriented, polymer/LC composite membranes had an excellent haemocompatibility, fewer platelets were adhered and spread and showed little distortion on the surface of materials.
制备了一系列聚合物/胆甾醇基液晶（LC）复合膜。将聚氨酯和聚氯乙烯作为基底，在正常条件下于电场中与四甘醇碳酸胆甾醇酯共混以形成复合膜。通过动态凝血试验、溶血率测量、血小板黏附及扫描电子显微镜观察来鉴定复合材料的血液相容性。结果表明，LC的含量、嵌入复合材料中的LC畴的有序程度以及基底的类型对聚合物/LC复合材料的血液相容性有较大影响。当LC畴取向适当时，聚合物/LC复合膜具有优异的血液相容性，黏附并铺展的血小板较少，且材料表面几乎没有变形。
