Tu Mei, Cha Zhen-Gang, Feng Bo-Hua, Zhou Chang-Ren
Department of Material Science and Engineering, Jinan University, Guangzhou, 510632, People's Republic of China.
Biomed Mater. 2006 Dec;1(4):202-5. doi: 10.1088/1748-6041/1/4/005. Epub 2006 Sep 13.
The objective of this study was to synthesize new types of cholesteric liquid crystal compounds and study the anticoagulative properties of their composite membranes. Three kinds of cholesteric liquid crystal compounds were synthesized and characterized by infrared spectroscopy, differential scanning calorimetry and optical polarizing microscope. The polysiloxane, as a substrate, was blended with three liquid crystal compounds and was then used as membranes. The anticoagulative property of different polysiloxane liquid crystal composite membranes was identified by the blood compatibility tests. Three cholesteryl liquid crystals synthesized in this work contained hydrophilic soft chains and presented iridescent texture owned by cholesteric liquid crystals in the range of their liquid crystal state temperature, but only cholesteryl acryloyl oxytetraethylene glycol carbonate was in the liquid crystal state at body temperature. When liquid crystals were blended with polysiloxane to form polysiloxane/liquid crystal composite membranes, the haemocompatibility of these membranes could be improved to some extent. The blood compatibility of composite membranes whose hydrophilic property was the best was more excellent than that of other composite membranes, fewer platelets adhered and spread, and showed little distortion on the surface of materials.
本研究的目的是合成新型胆甾相液晶化合物，并研究其复合膜的抗凝性能。合成了三种胆甾相液晶化合物，并通过红外光谱、差示扫描量热法和光学偏光显微镜对其进行了表征。以聚硅氧烷为基底，将其与三种液晶化合物共混后制成膜。通过血液相容性测试确定了不同聚硅氧烷液晶复合膜的抗凝性能。本工作合成的三种胆甾醇液晶含有亲水性软链，在其液晶态温度范围内呈现胆甾相液晶特有的虹彩织构，但只有丙烯酰氧基四甘醇碳酸胆甾醇酯在体温下处于液晶态。当液晶与聚硅氧烷共混形成聚硅氧烷/液晶复合膜时，这些膜的血液相容性可在一定程度上得到改善。亲水性最佳的复合膜的血液相容性比其他复合膜更优异，血小板黏附与铺展较少，材料表面几乎没有变形。
