Fedoseev G B, Emel'ianov A V, Malakauskas K K, Goncharova V A, Sinitsina T M, Didur M D, Emanuél' V L, Krunchak L V
Ter Arkh. 1991;63(12):27-9.
Twelve patients with preasthma (PA) and 27 bronchial asthma (BA) patients were examined for the effect of magnesium sulphate aerosol on bronchial sensitivity and reactivity to acetylcholine (ACC) and graded physical exercise (GPE) as well as on bronchial patency recorded by general plethysmography and pneumotachography. Inhalation of the drug was established to exert no bronchodilatory action but reduced, as compared with placebo, nonspecific hyperreactivity of the bronchial tree and blocked the ACC induced increment of histamine in the exhaled air condensate. The data obtained allow bronchial smooth muscles and mast cells to be regarded as targets for magnesium sulphate. The drug properties discovered may serve a prerequisite for its use in the combined treatment of BA patients and those with PA.
对12例哮喘前期（PA）患者和27例支气管哮喘（BA）患者进行了研究，以观察硫酸镁气雾剂对支气管对乙酰胆碱（ACC）和分级体育锻炼（GPE）的敏感性和反应性的影响，以及对通过总体积描记法和呼吸流速描记法记录的支气管通畅性的影响。已确定吸入该药物没有支气管扩张作用，但与安慰剂相比，可降低支气管树的非特异性高反应性，并阻止ACC诱导的呼出气冷凝物中组胺增加。所获得的数据使支气管平滑肌和肥大细胞可被视为硫酸镁的作用靶点。所发现的药物特性可能是其用于BA患者和PA患者联合治疗的前提条件。
