Emel'ianov A V, Fedoseev G B, Emanuél' V L, Sinitsina T M, Krunchak L V
Klin Med (Mosk). 1990 Nov;68(11):31-4.
Plethysmography and pneumotachography were applied to measure bronchial permeability, and reactivity of the bronchi in 10 patients with pre-asthma and 17 with asthma upon administration of magnesium sulfate aerosol (solution osmolality 260 mmol/l, pH-6.6). Though the drug inhalation did not induce bronchial dilatation, it diminished both hypersensitivity and hyperreactivity of the bronchial tree to acetylcholine. These properties of magnesium sulfate in the absence of unwanted sequelae when introduced endobronchially allow its advocating in combined treatment of asthma and pre-asthma.
采用体积描记法和呼吸流速描记法测量了10例哮喘前期患者和17例哮喘患者在吸入硫酸镁气雾剂（溶液渗透压260 mmol/l，pH值6.6）时的支气管通透性和支气管反应性。尽管药物吸入未引起支气管扩张，但它降低了支气管树对乙酰胆碱的超敏反应和高反应性。硫酸镁经支气管内给药时无不良后遗症的这些特性使其可用于哮喘和哮喘前期的联合治疗。
