Fedoseev G B, Emel'ianov A V, Sinitsina T M, Goncharova V A
Ter Arkh. 1995;67(3):32-4.
Ditec effects on clinicofunctional status were investigated in 15 patients with mild and moderate atopic bronchial asthma (ABA) aged 20-50 (5 males and 10 females). A single ditec dose had a broncholytic effect along the entire bronchial tree and reduced sensitivity to acetylcholine. Magnesium sulfate (a single dose 3 mmol Mg2+, pH 6.6, the solution osmolality 260 mmol/l) potentiated ditec action on nonspecific hyperreactivity of the bronchial tree. Four-week ditec course induced no considerable changes in bronchial permeability, but increased reversibility of bronchial obstruction, inhibited sensitivity and response of the bronchial tree to acetylcholine. Course administration of ditec lowered endobronchial concentration of histamine and lipid peroxidation intensity showing antiallergic and antiinflammatory properties of the drug. Ditec is recommended for ABA and other asthma forms treatment as a safe and effective modality.
对15名年龄在20至50岁之间（5名男性和10名女性）的轻中度特应性支气管哮喘（ABA）患者研究了Ditec对临床功能状态的影响。单次Ditec剂量对整个支气管树具有支气管溶解作用，并降低了对乙酰胆碱的敏感性。硫酸镁（单次剂量3 mmol Mg2 +，pH 6.6，溶液渗透压260 mmol / l）增强了Ditec对支气管树非特异性高反应性的作用。为期四周的Ditec疗程未引起支气管通透性的显著变化，但增加了支气管阻塞的可逆性，抑制了支气管树对乙酰胆碱的敏感性和反应。Ditec的疗程给药降低了支气管内组胺浓度和脂质过氧化强度，显示出该药物的抗过敏和抗炎特性。推荐将Ditec作为一种安全有效的方式用于ABA和其他哮喘形式的治疗。
