da Silva-Júnior F P, Carrasco A E A B, da Silva Mendes A M, Lopes A J T, Nobre E Souza M A, de Bruin V M S
Department of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil.
Neurogastroenterol Motil. 2008 Apr;20(4):285-90. doi: 10.1111/j.1365-2982.2007.01036.x. Epub 2007 Nov 23.
Although dysphagia is a common complaint of patients with Wilson's disease (WD) and pneumonia is an important cause of death in these patients, swallowing function remains an underinvestigated field in this condition. The aim of this study was to characterize swallowing dynamics in WD patients. Eight WD patients and 15 age-matched controls underwent scintigraphic evaluation of oral and pharyngeal deglutition. Patients had significantly slower oral transit (P = 0.008) and a greater percentage of oral residue (P = 0.006) when compared to controls. Two of eight patients were free of neurological symptoms at time of examination. Impaired oropharyngeal function was found in patients without dysphagia and without neurological symptoms. Our findings indicate that WD may present with objective swallowing dysfunction, even in the absence of neurological manifestations. Further studies are necessary to investigate the impact of this dysfunction on morbidity and mortality in WD.
尽管吞咽困难是威尔逊病（WD）患者的常见主诉，且肺炎是这些患者重要的死亡原因，但在这种情况下，吞咽功能仍是一个研究不足的领域。本研究的目的是描述WD患者的吞咽动力学特征。8例WD患者和15例年龄匹配的对照者接受了口腔和咽部吞咽的闪烁显像评估。与对照组相比，患者的口腔运送时间明显更慢（P = 0.008），口腔残留百分比更高（P = 0.006）。8例患者中有2例在检查时无神经症状。在无吞咽困难且无神经症状的患者中发现口咽功能受损。我们的研究结果表明，即使没有神经学表现，WD也可能存在客观的吞咽功能障碍。有必要进一步研究这种功能障碍对WD患者发病率和死亡率的影响。
