Badaeva L N, Nedorenko N I
Vrach Delo. 1991 Oct(10):68-71.
A study is presented of the placenta histogenesis and development of cardiotoxic effect in rat progeny under the effect of the synthetic pyrethroid decis. The drug was introduced to pregnant animals perorally in 1/20 and 1/100 LD50 doses during the critical periods of neonatal development. Morphological disorders were revealed as well as a reduction of enzymatic activity (OP, SDG) in the placenta and ultrastructural and histochemical disorders of these enzymes in the myocardium of the progeny at different periods of ontogenesis. The revealed changes evidence the capacity of the pyrethroid decis to penetrate through the placental barrier and produce a cardiolesioning effect on the progeny.
本文介绍了在合成拟除虫菊酯敌杀死作用下，大鼠后代胎盘组织发生及心脏毒性效应发展的研究。在新生儿发育的关键时期，将该药物以1/20和1/100 LD50剂量经口给予怀孕动物。在个体发育的不同时期，发现胎盘存在形态学紊乱以及酶活性（OP、SDG）降低，后代心肌中这些酶存在超微结构和组织化学紊乱。所揭示的变化证明了拟除虫菊酯敌杀死能够穿透胎盘屏障并对后代产生心脏损伤作用。
