Grigorian S S, Pritsker A D, Onufrieva E K, Chireshkin D G, Ershov F I
Vopr Virusol. 1991 Sep-Oct;36(5):407-9.
The influence of various interferon concentrations in vitro on alpha- and gamma-interferon production by lymphocytes of children suffering from respiratory papillomatosis was studied for optimization of interferon therapy. Most of the children with clinical improvement after interferon treatment showed proportional dependence of alpha-interferon production upon exogenous interferon concentrations and stability of gamma-interferon production. In children without clinical improvement, initial production of both interferons was reduced significantly in the absence of IF in the medium, but no changes occurred when exogenous interferon was present in the medium. The test proposed here may be used for the determination of patients' sensitivity to interferon and for individualization of interferon treatment schedules in other long-lasting recurrent diseases.
为优化干扰素治疗，研究了体外不同浓度干扰素对患呼吸道乳头状瘤病儿童淋巴细胞产生α-和γ-干扰素的影响。大多数经干扰素治疗后临床症状改善的儿童，其α-干扰素产生与外源性干扰素浓度呈比例相关，且γ-干扰素产生稳定。在临床症状未改善的儿童中，培养基中无干扰素时，两种干扰素的初始产生均显著降低，但培养基中存在外源性干扰素时则无变化。本文提出的检测方法可用于确定患者对干扰素的敏感性，并用于其他长期复发性疾病干扰素治疗方案的个体化。
