Pritsker A D, Grigorian S S, Onufrieva E K, Chireshkin D G, Ershov F I
Vopr Virusol. 1991 Sep-Oct;36(5):409-11.
A method to determine changes in the activity of natural killers (NK) in treatment of juvenile respiratory papillomatosis in children and correlation with the clinical course of the disease was developed and studies with whole blood specimens were carried out before interferon (IF) treatment and after it. Initially high levels of NK activity and their subsequent decline were observed in the cases where IF treatment had no effect, whereas initially low levels with subsequent increase after treatment or normal levels remaining unchanged in the course of treatment were typical of the patients manifesting some clinical effect of the treatment. These studies confirm the possibility of the modulating effect of IF, and the method may be used in mass surveys and working with children.
开发了一种用于确定儿童青少年呼吸道乳头状瘤病治疗中自然杀伤细胞（NK）活性变化及其与疾病临床进程相关性的方法，并在干扰素（IF）治疗前和治疗后对全血样本进行了研究。在IF治疗无效的病例中，最初观察到NK活性水平较高，随后下降；而在治疗表现出一定临床效果的患者中，典型特征是最初水平较低，治疗后升高，或在治疗过程中正常水平保持不变。这些研究证实了IF具有调节作用的可能性，该方法可用于大规模调查及儿童相关研究。
