Naiman H B, Doyle A T, Ruben R J, Kadish A S
Ann Otol Rhinol Laryngol. 1984 Sep-Oct;93(5 Pt 1):483-7. doi: 10.1177/000348948409300514.
The observation that interferon (IFN) therapy causes regression of lesions in some patients with recurrent respiratory papillomatosis (RRP) raises the possibilities that these patients may have abnormalities in endogenous IFN production or in antitumor immune responses stimulated by IFN. We have measured IFN production and natural cytotoxicity (NK activity) in nine patients with RRP, three of whom were receiving exogenous IFN at the time of testing. Production of IFN-gamma induced by the T cell mitogen Staphylococcus enterotoxin A was normal in all patients. Production of IFN-alpha induced by two viruses (Sendai and Newcastle disease viruses) was normal in the six untreated patients, but significantly lower in the patients on IFN therapy. Natural cytotoxicity against K562 target cells, both spontaneous and IFN-stimulated, was normal in all RRP patients tested. Thus, we have shown that the NK-IFN system was intact in untreated patients with RRP. IFN-alpha production in the RRP patients on IFN therapy was low. The significance of these findings is discussed.
干扰素（IFN）治疗可使部分复发性呼吸道乳头状瘤病（RRP）患者的病变消退，这一现象提示这些患者可能在内源性IFN产生或IFN刺激的抗肿瘤免疫反应方面存在异常。我们检测了9例RRP患者的IFN产生及自然细胞毒性（NK活性），其中3例在检测时正在接受外源性IFN治疗。所有患者经T细胞丝裂原金黄色葡萄球菌肠毒素A诱导产生的IFN-γ均正常。6例未接受治疗的患者经两种病毒（仙台病毒和新城疫病毒）诱导产生的IFN-α正常，但接受IFN治疗的患者其IFN-α产生显著降低。所有接受检测的RRP患者对K562靶细胞的自然细胞毒性，无论是自发的还是IFN刺激后的，均正常。因此，我们表明未经治疗的RRP患者的NK-IFN系统是完整的。接受IFN治疗的RRP患者的IFN-α产生较低。本文讨论了这些发现的意义。
