A-Elgadir Thoraya M E, Elbashir Mustafa I, Berzins Klavs, Masuadi Emad M, A-Elbasit Ishraga E, ElGhazali Gehad, Giha Hayder A
Malaria Research Centre, Department of Biochemistry, Faculty of Medicine, University of Khartoum, P.O. Box 102, Khartoum, Sudan.
Parasitol Res. 2008 Feb;102(3):401-9. doi: 10.1007/s00436-007-0777-3. Epub 2007 Nov 24.
In this study, antibodies (Ab) directed against three MSP antigens; MSP1(19), MSP2(A), and MSP2(B) were analyzed in blood samples obtained from 223 Sudanese patients who presented with either severe malaria (SM) or uncomplicated malaria (UM) and from 117 malaria-free donors (MF). The results showed that the prevalence of MSP Abs was associated with the clinical outcome of malaria infection, and the Ab prevalence was age-dependent (P<0.0005). More importantly, the prevalence of MSP Abs against the test antigens was lower in SM compared to UM (P=0.001 to 0.020), suggesting a protective role for these Abs against SM. Furthermore, the Ab responses between individual complications of SM were significantly different.
在本研究中，对来自223例患有严重疟疾（SM）或非复杂性疟疾（UM）的苏丹患者以及117例无疟疾供体（MF）的血液样本中针对三种MSP抗原（MSP1(19)、MSP2(A)和MSP2(B)）的抗体（Ab）进行了分析。结果表明，MSP抗体的流行率与疟疾感染的临床结果相关，且抗体流行率与年龄有关（P<0.0005）。更重要的是，与UM相比，SM中针对测试抗原的MSP抗体流行率较低（P=0.001至0.020），表明这些抗体对SM具有保护作用。此外，SM个体并发症之间的抗体反应存在显著差异。
