肠炎沙门氏菌鼠伤寒血清型中Hha-YdgT蛋白对水平获得基因的调控
Modulation of horizontally acquired genes by the Hha-YdgT proteins in Salmonella enterica serovar Typhimurium.
作者信息
Vivero Aitziber, Baños Rosa C, Mariscotti Javier F, Oliveros Juan Carlos, García-del Portillo Francisco, Juárez Antonio, Madrid Cristina
机构信息
Departament de Microbiologia, Universitat de Barcelona, Avda. Diagonal 645, 08028 Barcelona, Spain.
出版信息
J Bacteriol. 2008 Feb;190(3):1152-6. doi: 10.1128/JB.01206-07. Epub 2007 Nov 26.
Abstract
We describe a transcriptomic study of the effect of hha and ydgT mutations in Salmonella enterica serovar Typhimurium. A large number of genes showing altered expression are located in AT-rich horizontally acquired DNA sequences. Many of these genes have also been reported to be targets for H-NS. As Hha and YdgT interact with H-NS, our findings strongly suggest that Hha and/or YdgT must form complexes with H-NS when they silence these DNA regions.
摘要
我们描述了一项关于肠炎沙门氏菌鼠伤寒血清型中hha和ydgT突变影响的转录组学研究。大量显示表达改变的基因位于富含AT的水平获得性DNA序列中。据报道，其中许多基因也是H-NS的作用靶点。由于Hha和YdgT与H-NS相互作用，我们的研究结果强烈表明，当Hha和/或YdgT使这些DNA区域沉默时，它们必须与H-NS形成复合物。
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2
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3
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