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本文引用的文献

1
The response regulator SsrB activates expression of diverse Salmonella pathogenicity island 2 promoters and counters silencing by the nucleoid-associated protein H-NS.应答调节因子SsrB可激活多种沙门氏菌致病岛2启动子的表达，并对抗类核相关蛋白H-NS介导的基因沉默。
Mol Microbiol. 2007 Jul;65(2):477-93. doi: 10.1111/j.1365-2958.2007.05800.x.
2
Repression of intracellular virulence factors in Salmonella by the Hha and YdgT nucleoid-associated proteins.Hha和YdgT类核相关蛋白对沙门氏菌细胞内毒力因子的抑制作用。
J Bacteriol. 2007 May;189(9):3669-73. doi: 10.1128/JB.00002-07. Epub 2007 Feb 16.
3
H-NS, the genome sentinel.H-NS，基因组哨兵。
Nat Rev Microbiol. 2007 Feb;5(2):157-61. doi: 10.1038/nrmicro1598. Epub 2006 Dec 27.
4
The novel Hha/YmoA family of nucleoid-associated proteins: use of structural mimicry to modulate the activity of the H-NS family of proteins.新型类核相关蛋白Hha/YmoA家族：利用结构模拟调节H-NS蛋白家族的活性
Mol Microbiol. 2007 Jan;63(1):7-14. doi: 10.1111/j.1365-2958.2006.05497.x. Epub 2006 Nov 14.
5
Molecular evolution of the H-NS protein: interaction with Hha-like proteins is restricted to enterobacteriaceae.H-NS蛋白的分子进化：与类Hha蛋白的相互作用仅限于肠杆菌科。
J Bacteriol. 2007 Jan;189(1):265-8. doi: 10.1128/JB.01124-06. Epub 2006 Oct 13.
6
H-NS mediates the silencing of laterally acquired genes in bacteria.H-NS介导细菌中横向获得基因的沉默。
PLoS Pathog. 2006 Aug;2(8):e81. doi: 10.1371/journal.ppat.0020081.
7
H-NS gives invading DNA the silent treatment.H-NS对入侵的DNA进行沉默处理。
Nat Chem Biol. 2006 Aug;2(8):400-1. doi: 10.1038/nchembio0806-400.
8
H-NS represses inv transcription in Yersinia enterocolitica through competition with RovA and interaction with YmoA.H-NS通过与RovA竞争并与YmoA相互作用来抑制小肠结肠炎耶尔森菌中的inv转录。
J Bacteriol. 2006 Jul;188(14):5101-12. doi: 10.1128/JB.00862-05.
9
Selective silencing of foreign DNA with low GC content by the H-NS protein in Salmonella.鼠伤寒沙门氏菌中H-NS蛋白对低GC含量外源DNA的选择性沉默作用
Science. 2006 Jul 14;313(5784):236-8. doi: 10.1126/science.1128794. Epub 2006 Jun 8.
10
New roles for key residues in helices H1 and H2 of the Escherichia coli H-NS N-terminal domain: H-NS dimer stabilization and Hha binding.大肠杆菌H-NS N端结构域H1和H2螺旋中关键残基的新作用：H-NS二聚体稳定及与Hha结合
J Mol Biol. 2006 Jun 9;359(3):679-89. doi: 10.1016/j.jmb.2006.03.059. Epub 2006 Apr 18.

肠炎沙门氏菌鼠伤寒血清型中Hha-YdgT蛋白对水平获得基因的调控

Modulation of horizontally acquired genes by the Hha-YdgT proteins in Salmonella enterica serovar Typhimurium.

作者信息

Vivero Aitziber, Baños Rosa C, Mariscotti Javier F, Oliveros Juan Carlos, García-del Portillo Francisco, Juárez Antonio, Madrid Cristina

机构信息

Departament de Microbiologia, Universitat de Barcelona, Avda. Diagonal 645, 08028 Barcelona, Spain.

出版信息

J Bacteriol. 2008 Feb;190(3):1152-6. doi: 10.1128/JB.01206-07. Epub 2007 Nov 26.

DOI:10.1128/JB.01206-07
PMID:18039769
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2223552/
Abstract

We describe a transcriptomic study of the effect of hha and ydgT mutations in Salmonella enterica serovar Typhimurium. A large number of genes showing altered expression are located in AT-rich horizontally acquired DNA sequences. Many of these genes have also been reported to be targets for H-NS. As Hha and YdgT interact with H-NS, our findings strongly suggest that Hha and/or YdgT must form complexes with H-NS when they silence these DNA regions.

摘要

我们描述了一项关于肠炎沙门氏菌鼠伤寒血清型中hha和ydgT突变影响的转录组学研究。大量显示表达改变的基因位于富含AT的水平获得性DNA序列中。据报道，其中许多基因也是H-NS的作用靶点。由于Hha和YdgT与H-NS相互作用，我们的研究结果强烈表明，当Hha和/或YdgT使这些DNA区域沉默时，它们必须与H-NS形成复合物。