Devesa M, Loureiro C L, Rivas Y, Monsalve F, Cardona N, Duarte M C, Poblete F, Gutierrez M F, Botto C, Pujol F H
Laboratorio de Virología Molecular, CMBC, IVIC, Caracas, Venezuela.
J Med Virol. 2008 Jan;80(1):20-6. doi: 10.1002/jmv.21024.
The objective of this study was the evaluation of the genetic diversity found in HBV circulating among Venezuelan Amerindians and the general population in Colombia. Phylogenetic analysis of the S region in 194 isolates showed that genotype F is highly predominant in Colombia and Venezuela. This might be related to the genetic background of the population. F3 is the main subgenotype which circulates in both countries. Phylogenetic analysis of 61 complete genome sequences of HBV American genotypes confirms the presence of two genotypes F and H, and 4 F subgenotypes. In Venezuela, subgenotypes F1, F2, and F3 circulate in East and West Amerindians, while only F3 was found among South Amerindians. Japreira community derived from Yucpa Amerindians around 150 years ago. However, several Japreira HBV sequences were forming a clade that can be classified as subgenotype 2b, differing from Yucpa sequences that belong mainly to subgenotype F3. The apparent absence of correlation between the phylogenetic groupings of HBV isolates with the ethnical origin in aboriginal populations might be suggesting a recent origin of HBV American subgenotypes, or a genetic drift effect.
本研究的目的是评估在委内瑞拉美洲印第安人和哥伦比亚普通人群中传播的乙肝病毒（HBV）的遗传多样性。对194株病毒分离株的S区域进行系统发育分析表明，F基因型在哥伦比亚和委内瑞拉高度占主导地位。这可能与人群的遗传背景有关。F3是在这两个国家传播的主要亚基因型。对美洲HBV基因型的61个完整基因组序列进行系统发育分析，证实存在F和H两种基因型以及4种F亚基因型。在委内瑞拉，F1、F2和F3亚基因型在东部和西部美洲印第安人中传播，而在南部美洲印第安人中仅发现F3。Japreira群落大约在150年前源自Yucpa美洲印第安人。然而，一些Japreira HBV序列形成了一个可归类为2b亚基因型的分支，这与主要属于F3亚基因型的Yucpa序列不同。HBV分离株的系统发育分组与原住民种族起源之间明显缺乏相关性，这可能表明美洲HBV亚基因型起源较近，或者存在遗传漂变效应。
