Rusthoven Kyle, Ballonoff Ari, Raben David, Chen Changhu
Department of Radiation Oncology, University of Colorado Denver, Aurora, Colorado 80045-0508, USA.
Cancer. 2008 Jan 15;112(2):345-51. doi: 10.1002/cncr.23183.
The objective of this study was to compare survival in patients with squamous cell carcinoma (SCC) of the oral tongue with that in patients with SCC in other oral cavity subsites.
Patients with stage I and II (T1-T2N0M0) SCC of the oral cavity diagnosed between 1988 and 2004 were queried by using the Surveillance, Epidemiology, and End Results (SEER) database. The log-rank test was used to compare the overall survival (OS) and cause-specific survival (CSS) of patients who had oral tongue SCC with those of patients who had SCC of other oral cavity subsites. A Cox proportional hazards multivariate analysis was performed to evaluate the influence of covariates on the risk of CSS and OS.
Between 1988 and 2004, 6791 patients with stage I and II SCC of the oral cavity were identified. Among them, 40% had oral tongue SCC, and 60% had SCC of other oral cavity subsites. The median patient age was 64 years. The 5-year OS and CSS rates were 60.9% and 83.5%, respectively, for patients with oral tongue SCC versus 64.7% and 94.1%, respectively, for patients with SCC of other oral cavity subsites (OS: hazard ratio, 1.24; P< .0001; CSS: hazard ratio, 3.04; P< .0001). On multivariate analysis, OS and CSS were influenced significantly by T classification, age, sex, and oral tongue subsite. The CSS for patients who had stage I and II oral tongue SCC also was unfavorable compared with the CSS for stage-matched patients who had SCC of other head and neck sites.
Oral tongue SCC was associated with poor survival compared with other oral cavity and head and neck sites. These data suggested a potential benefit for multimodality therapy in this cohort of patients.
本研究的目的是比较口腔舌鳞状细胞癌（SCC）患者与其他口腔亚部位SCC患者的生存率。
利用监测、流行病学和最终结果（SEER）数据库查询1988年至2004年间诊断为I期和II期（T1 - T2N0M0）口腔SCC的患者。采用对数秩检验比较口腔舌SCC患者与其他口腔亚部位SCC患者的总生存期（OS）和病因特异性生存期（CSS）。进行Cox比例风险多变量分析以评估协变量对CSS和OS风险的影响。
在1988年至2004年间，确定了6791例I期和II期口腔SCC患者。其中，40%患有口腔舌SCC，60%患有其他口腔亚部位SCC。患者中位年龄为64岁。口腔舌SCC患者的5年OS率和CSS率分别为60.9%和83.5%，而其他口腔亚部位SCC患者分别为64.7%和94.1%（OS：风险比，1.24；P <.0001；CSS：风险比，3.04；P <.0001）。多变量分析显示，OS和CSS受T分类、年龄、性别和口腔舌亚部位的显著影响。与其他头颈部部位SCC的分期匹配患者相比，I期和II期口腔舌SCC患者的CSS也较差。
与其他口腔及头颈部部位相比，口腔舌SCC与较差的生存率相关。这些数据表明对该组患者进行多模式治疗可能有益。
