da Silva Souto Ana Carolina, da Silva Beatriz Nascimento Monteiro, Heimlich Fernanda Vieira, Soares Otávio Augusto Brioschi, Dias Fernando Luiz, de Lima Araujo Luiz Henrique, de Melo Andreia Cristina, Antunes Héliton Spindola, Santos Thuler Luiz Claudio, Goldemberg Daniel Cohen
Army Health Service Research Center, Army Central Hospital, Rio de Janeiro, Brazil.
Division of Clinical Research, Technological Development of the National Cancer Institute, Rio de Janeiro, Brazil.
Sci Rep. 2024 Dec 20;14(1):30573. doi: 10.1038/s41598-024-83470-9.
This study investigates the changing epidemiological profile of tongue squamous cell carcinoma (SCC) to young patients, highlighting its rising incidence among non-traditional risk groups. A retrospective descriptive study was conducted, covering data from medical records between 2000 and 2012. Patients were categorised into two age groups (≤ 40 years; 41-50 years). Sociodemographic and clinicopathological characteristics were evaluated. A total of 108 patients participated, mostly aged 41-50. Alcohol consumption (43.3%) surpassed smoking. Majority (56.7%) aged ≤ 40 never smoked. Lateral tongue border was most affected, with stages III and IV prevalent. Patients aged ≤ 40 were mostly eligible for surgery (44%). Survival tied to staging and surgery; age had no significant impact. Young squamous cell carcinoma patients often lacked traditional risk factors like smoking, underwent surgery, and typically had disease-free margins. The study underscores the importance of broad external policies for early diagnosis, beyond just traditional risk groups.
本研究调查了舌鳞状细胞癌（SCC）在年轻患者中不断变化的流行病学特征，突出了其在非传统风险人群中发病率的上升。进行了一项回顾性描述性研究，涵盖了2000年至2012年病历中的数据。患者被分为两个年龄组（≤40岁；41 - 50岁）。评估了社会人口统计学和临床病理特征。共有108名患者参与，大多数年龄在41 - 50岁。饮酒（43.3%）超过吸烟。大多数（56.7%）年龄≤40岁的患者从不吸烟。舌外侧缘受影响最严重，Ⅲ期和Ⅳ期较为普遍。年龄≤40岁的患者大多符合手术条件（44%）。生存率与分期和手术有关；年龄没有显著影响。年轻的鳞状细胞癌患者通常缺乏吸烟等传统风险因素，接受了手术，且通常切缘无肿瘤。该研究强调了广泛的外部政策对于早期诊断的重要性，而不仅仅局限于传统风险人群。
