Treilleux I, d'Agay M F, Bryon P A, Berger F
Laboratoire d'Anatomie Pathologique, Hôpital E. Herriot, Lyon.
Ann Pathol. 1991;11(5-6):326-33.
Histiocytic necrotizing lymphadenitis of Kikuchi is a rare benign disease. Characteristically, patients are young women with cervical adenopathy which may be associated with fever. Histologically, the involved lymph nodes show focal, well-circumscribed, paracortical, necrotizing lesions which contain karyorrhectic debris and aggregates of large mononuclear cells but no neutrophils. This disorder can be misdiagnosed as malignant lymphoma. The histological features seem to be related to delayed-type hypersensitivity but the antigenic stimulus is still unknown. The clinicopathological and immunohistochemical features of histiocytic necrotizing lymphadenitis in 11 patients are described. In necrotic areas, the majority of cells represent histiocytes and T cells (predominantly of CD8 phenotype). The involved lymph nodes were localized to several cervical sites (commonly jugular area).
菊池氏组织细胞坏死性淋巴结炎是一种罕见的良性疾病。其特点是患者多为年轻女性，伴有颈部淋巴结肿大，可能伴有发热。组织学上，受累淋巴结表现为局灶性、边界清楚的副皮质坏死性病变，其中含有核碎裂碎片和大单核细胞聚集，但无中性粒细胞。这种疾病可能被误诊为恶性淋巴瘤。其组织学特征似乎与迟发型超敏反应有关，但抗原刺激仍不清楚。本文描述了11例组织细胞坏死性淋巴结炎的临床病理和免疫组化特征。在坏死区域，大多数细胞为组织细胞和T细胞（主要为CD8表型）。受累淋巴结局限于几个颈部部位（常见于颈静脉区）。
