Silkin Lara, Hamza Shereen, Kaufman Susan, Cobb Steven L, Vederas John C
Department of Chemistry, University of Alberta, Edmonton, Alta., Canada T6G 2G2.
Bioorg Med Chem Lett. 2008 May 15;18(10):3103-6. doi: 10.1016/j.bmcl.2007.11.024. Epub 2007 Nov 17.
Spermicidal compounds that also exhibit antimicrobial properties would be extremely attractive agents as they could be used to not only prevent unwanted pregnancy but also to combat the growing prevalence of sexually transmitted infections (STI). One class of compounds that are potential candidates for development of dual-acting contraceptive products are antimicrobial peptides (AMPs). Herein, we report preliminary studies carried out to investigate the spermicidal activity of two bacteriocins, lacticin 3147 and subtilosin A, on bovine, horse/pony, boar and rat sperm.
同时具有抗菌特性的杀精化合物将是极具吸引力的药物，因为它们不仅可用于预防意外怀孕，还能对抗日益普遍的性传播感染（STI）。抗菌肽（AMPs）是一类有潜力用于开发双效避孕产品的化合物。在此，我们报告了为研究两种细菌素——乳酸链球菌素3147和枯草芽孢杆菌素A对牛、马/小马、猪和大鼠精子的杀精活性而开展的初步研究。
