Poly Frédéric, Guerry Patricia
Enteric Diseases Department, Naval Medical Research Center, Silver Spring, Maryland 20910, USA.
Curr Opin Gastroenterol. 2008 Jan;24(1):27-31. doi: 10.1097/MOG.0b013e3282f1dcb1.
Molecular pathogenesis of Campylobacter jejuni has lagged behind that of other enteric pathogens. This review summarizes advances in the biology and pathogenesis of C. jejuni.
Multiple genome sequences have defined conserved and hypervariable loci in the C. jejuni genome. Interaction of C. jejuni with eukaryotic cells results in numerous signal transduction changes and release of proinflammatory cytokines. In-vivo models based on immune knockout mice have also revealed new information on pathogenesis.
New information and new methods are available that should provide important tools to further understand pathogenesis of this elusive pathogen.
空肠弯曲菌的分子发病机制落后于其他肠道病原体。本综述总结了空肠弯曲菌生物学和发病机制方面的进展。
多个基因组序列已确定了空肠弯曲菌基因组中的保守和高变位点。空肠弯曲菌与真核细胞的相互作用导致大量信号转导变化和促炎细胞因子的释放。基于免疫敲除小鼠的体内模型也揭示了有关发病机制的新信息。
现有新信息和新方法，应能为进一步了解这种难以捉摸的病原体的发病机制提供重要工具。
