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Targeted metabolomics analysis of Campylobacter coli VC167 reveals legionaminic acid derivatives as novel flagellar glycans.空肠弯曲杆菌VC167的靶向代谢组学分析揭示了Legionaminic酸衍生物作为新型鞭毛聚糖。
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2
Conjugative transfer of chromosomally encoded antibiotic resistance from Helicobacter pylori to Campylobacter jejuni.染色体编码的抗生素耐药性从幽门螺杆菌向空肠弯曲菌的接合转移。
J Clin Microbiol. 2007 Feb;45(2):402-8. doi: 10.1128/JCM.01456-06. Epub 2006 Nov 29.
3
Comparative genomic analysis of Campylobacter jejuni strains reveals diversity due to genomic elements similar to those present in C. jejuni strain RM1221.空肠弯曲菌菌株的比较基因组分析揭示了由于与空肠弯曲菌RM1221菌株中存在的基因组元件相似而导致的多样性。
J Clin Microbiol. 2006 Nov;44(11):4125-35. doi: 10.1128/JCM.01231-06. Epub 2006 Aug 30.
4
Unique features of a highly pathogenic Campylobacter jejuni strain.高致病性空肠弯曲菌菌株的独特特征。
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Changes in flagellin glycosylation affect Campylobacter autoagglutination and virulence.鞭毛蛋白糖基化的变化会影响弯曲杆菌的自凝作用和毒力。
Mol Microbiol. 2006 Apr;60(2):299-311. doi: 10.1111/j.1365-2958.2006.05100.x.
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A sigma28-regulated nonflagella gene contributes to virulence of Campylobacter jejuni 81-176.一个受σ28调控的非鞭毛基因有助于空肠弯曲菌81-176的毒力。
Infect Immun. 2006 Jan;74(1):769-72. doi: 10.1128/IAI.74.1.769-772.2006.
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Genome sequencing in microfabricated high-density picolitre reactors.微制造高密度皮升反应器中的基因组测序
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9
Comparison of Campylobacter jejuni lipooligosaccharide biosynthesis loci from a variety of sources.不同来源空肠弯曲菌脂寡糖生物合成基因座的比较。
J Clin Microbiol. 2005 Jun;43(6):2771-81. doi: 10.1128/JCM.43.6.2771-2781.2005.
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Mosaic structure of a multiple-drug-resistant, conjugative plasmid from Campylobacter jejuni.空肠弯曲菌多重耐药接合性质粒的镶嵌结构
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来自泰国的空肠弯曲菌临床分离株的基因组序列。

Genome sequence of a clinical isolate of Campylobacter jejuni from Thailand.

作者信息

Poly Frédéric, Read Timothy, Tribble David R, Baqar Shahida, Lorenzo Maria, Guerry Patricia

机构信息

Enteric Diseases Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20906, USA.

出版信息

Infect Immun. 2007 Jul;75(7):3425-33. doi: 10.1128/IAI.00050-07. Epub 2007 Apr 16.

DOI:10.1128/IAI.00050-07
PMID:17438034
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1932940/
Abstract

Campylobacter jejuni CG8486, which belongs to the HS4 complex, was isolated from a patient with inflammatory diarrhea in Thailand. This strain caused a diarrheal disease in ferrets comparable to that caused by C. jejuni strain 81-176, but it was much less invasive for epithelial cells in vitro than 81-176. Complete genome sequencing of CG8486 revealed a 1.65-Mb genome that was very similar to the other two published genomes of clinical isolates of C. jejuni, the genomes of 81-176 and NCTC 11168, with a limited number of CG8486-specific genes mapping outside the hypervariable carbohydrate biosynthesis loci. These data suggest that the genes required for induction of inflammatory diarrhea are among the genes shared by CG8486 and 81-176 but that either major changes in the carbohydrate loci and/or more subtle changes in other genes may modulate virulence.

摘要

空肠弯曲菌CG8486属于HS4复合体，是从泰国一名患有炎性腹泻的患者体内分离出来的。该菌株在雪貂中引起的腹泻病与空肠弯曲菌81-176菌株所致的腹泻病相当，但在体外对上皮细胞的侵袭性比81-176菌株小得多。CG8486的全基因组测序显示其基因组大小为1.65 Mb，与另外两个已发表的空肠弯曲菌临床分离株基因组（81-176和NCTC 11168的基因组）非常相似，只有少数CG8486特异性基因定位于高变碳水化合物生物合成位点之外。这些数据表明，诱导炎性腹泻所需的基因存在于CG8486和81-176共有的基因之中，但碳水化合物位点的重大变化和/或其他基因的更细微变化可能会调节毒力。