Chaouat Gérard, Dubanchet Sylvie, Ledée Nathalie
U 782 INSERM, Equipe cytokines et dialogue cytokinique mère conceptus, Université Paris Sud et Hôpîtal Antoine Béclère, 32 rue des Carnets, Clamart Cedex, France.
J Assist Reprod Genet. 2007 Nov;24(11):491-505. doi: 10.1007/s10815-007-9142-9. Epub 2007 Nov 28.
Cytokines are obviously very important in an established pregnancy, but what about human embryo implantation?
Literature review.
We first discuss the necessity and limits of animal models, and then review the few cytokines which have been demonstrated by knock-out methods to be absolutely necessary for embryo implantation using in animal models. We then review what is known or discussed about the role of other cytokines as deduced from quantitative and/or qualitative dysregulation in animals and in humans.
Cytokines are indeed involved in implantation as they are in ongoing pregnancy and delivery. Relevance to infertility and recurrent pregnancy loss is discussed.
细胞因子在已建立的妊娠中显然非常重要，但在人类胚胎着床方面呢？
文献综述。
我们首先讨论动物模型的必要性和局限性，然后回顾通过基因敲除方法已证实在动物模型中对胚胎着床绝对必要的少数细胞因子。接着，我们回顾从动物和人类的定量和/或定性失调推断出的关于其他细胞因子作用的已知或讨论内容。
细胞因子确实如在持续妊娠和分娩中一样参与着床过程。并讨论了其与不孕症和复发性流产的相关性。
