Banasr Mounira, Duman Ronald S
Laboratory of Molecular Psychiatry, Center for Genes and Behavior, Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06508, USA.
CNS Neurol Disord Drug Targets. 2007 Oct;6(5):311-20. doi: 10.2174/187152707783220929.
Structural and morphological changes in limbic brain regions are associated with depression, chronic stress and antidepressant treatment, and increasing evidence supports the hypothesis that dysregulation of cell proliferation contributes to these effects. We review the morphological alterations observed in two brain regions implicated in mood disorders, the prefrontal cortex and hippocampus, and discuss the similarities and differences of the cellular consequences of chronic stress. We briefly discuss the proposed mechanisms implicated in neuroplasticity impairments that result from stress and that contribute to mood disorders, with a particular interest in adult neurogenesis and gliogenesis. This information has contributed to novel antidepressant medication development that utilizes adult neurogenesis and gliogenesis as preclinical cellular markers for predicting antidepressant properties of novel compounds.
边缘脑区的结构和形态变化与抑郁症、慢性应激及抗抑郁治疗有关，越来越多的证据支持细胞增殖失调导致这些效应的假说。我们综述了在与情绪障碍相关的两个脑区，即前额叶皮质和海马体中观察到的形态学改变，并讨论了慢性应激细胞后果的异同。我们简要讨论了应激导致的、并促成情绪障碍的神经可塑性损伤所涉及的机制，尤其关注成年神经发生和神经胶质生成。这些信息推动了新型抗抑郁药物的研发，该研发将成年神经发生和神经胶质生成作为预测新型化合物抗抑郁特性的临床前细胞标志物。
