从病理生理学到新型抗抑郁药物：神经胶质细胞对心境障碍的病理和治疗的贡献。
From pathophysiology to novel antidepressant drugs: glial contributions to the pathology and treatment of mood disorders.
机构信息
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.
出版信息
Biol Psychiatry. 2013 Jun 15;73(12):1172-9. doi: 10.1016/j.biopsych.2013.03.032.
Abstract
Several structural and cellular changes, including marked glial anomalies, have been observed in association with major depressive disorder. Here we review these cellular alterations and highlight the importance of glial cell pathology, especially astroglial dysfunction, in the pathophysiology of neuropsychiatric disorders with a particular interest in major depressive disorder. The functional role of astrocytes in glutamate uptake and glutamate/glutamine cycling is discussed, as is the deleterious effects of chronic stress on glial cell function. Lastly, we discuss the effect of antidepressants on glial cell function and the possibility of targeting glial cells in the quest to develop novel therapeutics.
摘要
已经观察到与重度抑郁症相关的几种结构和细胞变化，包括明显的神经胶质异常。在这里，我们回顾了这些细胞变化，并强调了神经胶质细胞病理学的重要性，特别是星形胶质细胞功能障碍，在神经精神疾病的病理生理学中的重要性，特别是在重度抑郁症中。我们讨论了星形胶质细胞在谷氨酸摄取和谷氨酸/谷氨酰胺循环中的功能作用，以及慢性应激对神经胶质细胞功能的有害影响。最后，我们讨论了抗抑郁药对神经胶质细胞功能的影响，以及在寻求开发新的治疗方法时靶向神经胶质细胞的可能性。
相似文献
1
From pathophysiology to novel antidepressant drugs: glial contributions to the pathology and treatment of mood disorders.从病理生理学到新型抗抑郁药物：神经胶质细胞对心境障碍的病理和治疗的贡献。
Biol Psychiatry. 2013 Jun 15;73(12):1172-9. doi: 10.1016/j.biopsych.2013.03.032.
2
Cell atrophy and loss in depression: reversal by antidepressant treatment.抑郁症中的细胞萎缩和丧失：抗抑郁治疗的逆转。
Curr Opin Cell Biol. 2011 Dec;23(6):730-7. doi: 10.1016/j.ceb.2011.09.002. Epub 2011 Oct 11.
3
Astroglial Connexin43 as a Potential Target for a Mood Stabiliser.星形胶质细胞连接蛋白43作为情绪稳定剂的潜在靶点。
Int J Mol Sci. 2020 Dec 30;22(1):339. doi: 10.3390/ijms22010339.
4
Regulation of neurogenesis and gliogenesis by stress and antidepressant treatment.应激和抗抑郁治疗对神经发生和胶质细胞生成的调节
CNS Neurol Disord Drug Targets. 2007 Oct;6(5):311-20. doi: 10.2174/187152707783220929.
5
Altered glial plasticity in animal models for mood disorders.情绪障碍动物模型中的神经胶质可塑性改变。
Curr Drug Targets. 2013 Oct;14(11):1249-61. doi: 10.2174/1389450111314110005.
6
Morphological brain changes in depression: can antidepressants reverse them?抑郁症患者大脑的形态学变化：抗抑郁药能否逆转这些变化？
CNS Drugs. 2002;16(6):361-72. doi: 10.2165/00023210-200216060-00001.
7
[Not Available].[无可用内容]
Drug Res (Stuttg). 2017 Nov;67(S 01):S21-S22. doi: 10.1055/s-0043-116527. Epub 2017 Oct 25.
8
Role of glial cell line-derived neurotrophic factor in the pathogenesis and treatment of mood disorders.胶质细胞源性神经营养因子在情绪障碍发病机制及治疗中的作用。
Rev Neurosci. 2017 Apr 1;28(3):219-233. doi: 10.1515/revneuro-2016-0063.
9
Talking to the synapse: how antidepressants can target glial cells to reshape brain circuits.与突触对话：抗抑郁药如何靶向神经胶质细胞重塑大脑回路。
Curr Drug Targets. 2013 Oct;14(11):1329-35. doi: 10.2174/1389450111314110011.
10
Serum S100B represents a new biomarker for mood disorders.血清 S100B 是一种新的情绪障碍生物标志物。
Curr Drug Targets. 2013 Oct;14(11):1237-48. doi: 10.2174/13894501113149990014.
引用本文的文献
1
Prefrontal contribution to passive coping behaviour in chronic stress and treatment by fast-acting antidepressant.前额叶对慢性应激中被动应对行为的作用及速效抗抑郁药的治疗作用
Neuropsychopharmacology. 2025 Aug 16. doi: 10.1038/s41386-025-02200-5.
2
Multi-omics approach identifies gut microbiota variations associated with depression.多组学方法识别出与抑郁症相关的肠道微生物群变化。
NPJ Biofilms Microbiomes. 2025 Apr 28;11(1):68. doi: 10.1038/s41522-025-00707-9.
3
Possible antidepressant mechanism of acupuncture: targeting neuroplasticity.针灸可能的抗抑郁机制：针对神经可塑性。
Front Neurosci. 2025 Feb 13;19:1512073. doi: 10.3389/fnins.2025.1512073. eCollection 2025.
4
Elevated neuron specific enolase levels in post-traumatic stress disorder.创伤后应激障碍患者神经元特异性烯醇化酶水平升高。
Eur J Pediatr. 2024 Nov 25;184(1):41. doi: 10.1007/s00431-024-05889-6.
5
Uric Acid: A Biomarker and Pathogenic Factor of Affective Disorders and Neurodegenerative Diseases.尿酸：情感障碍和神经退行性疾病的生物标志物及致病因素
Curr Pharm Des. 2025;31(8):585-597. doi: 10.2174/0113816128333916241003180018.
6
Astroglial Dysfunctions in Mood Disorders and Rodent Stress Models: Consequences on Behavior and Potential as Treatment Target.情绪障碍和啮齿动物应激模型中的星形胶质细胞功能障碍：对行为的影响及其作为治疗靶点的潜力。
Int J Mol Sci. 2024 Jun 8;25(12):6357. doi: 10.3390/ijms25126357.
7
Glial Markers of Suicidal Behavior in the Human Brain-A Systematic Review of Postmortem Studies.人脑自杀行为的神经胶质标志物：一项基于尸检研究的系统综述。
Int J Mol Sci. 2024 May 25;25(11):5750. doi: 10.3390/ijms25115750.
8
ER stress in mouse serotonin neurons triggers a depressive phenotype alleviated by ketamine targeting eIF2α signaling.小鼠血清素神经元中的内质网应激引发一种抑郁表型，氯胺酮靶向真核起始因子2α信号通路可缓解该表型。
iScience. 2024 Apr 18;27(5):109787. doi: 10.1016/j.isci.2024.109787. eCollection 2024 May 17.
9
The Role of Glutamine Homeostasis in Emotional and Cognitive Functions.谷氨酰胺稳态在情绪和认知功能中的作用
Int J Mol Sci. 2024 Jan 21;25(2):1302. doi: 10.3390/ijms25021302.
10
SYK-623, a δ Opioid Receptor Inverse Agonist, Mitigates Chronic Stress-Induced Behavioral Abnormalities and Disrupted Neurogenesis.SYK-623，一种δ阿片受体反向激动剂，可减轻慢性应激诱导的行为异常和神经发生紊乱。
J Clin Med. 2024 Jan 21;13(2):608. doi: 10.3390/jcm13020608.
本文引用的文献
1
Chronic restraint stress decreases glial fibrillary acidic protein and glutamate transporter in the periaqueductal gray matter.慢性束缚应激会降低脑桥导水管周围灰质中的神经胶质原纤维酸性蛋白和谷氨酸转运体。
Neuroscience. 2012 Oct 25;223:209-18. doi: 10.1016/j.neuroscience.2012.08.007. Epub 2012 Aug 10.
2
The immune theory of psychiatric diseases: a key role for activated microglia and circulating monocytes.精神疾病的免疫理论：激活的小胶质细胞和循环单核细胞的关键作用。
J Leukoc Biol. 2012 Nov;92(5):959-75. doi: 10.1189/jlb.0212100. Epub 2012 Aug 8.
3
Synaptic and extrasynaptic NMDA receptors are gated by different endogenous coagonists.突触和 extrasynaptic NMDA 受体由不同的内源性共激动剂门控。
Cell. 2012 Aug 3;150(3):633-46. doi: 10.1016/j.cell.2012.06.029.
4
A putative functional role for oligodendrocytes in mood regulation.少突胶质细胞在情绪调节中的推测功能作用。
Transl Psychiatry. 2012 May 1;2(5):e109. doi: 10.1038/tp.2012.34.
5
Regional astrocyte allocation regulates CNS synaptogenesis and repair.区域性星形胶质细胞的分配调节中枢神经系统的突触发生和修复。
Science. 2012 Jul 20;337(6092):358-62. doi: 10.1126/science.1222381. Epub 2012 Jun 28.
6
Microglia as modulators of cognition and neuropsychiatric disorders.小胶质细胞作为认知和神经精神疾病的调节剂。
Glia. 2013 Jan;61(1):62-70. doi: 10.1002/glia.22372. Epub 2012 Jun 27.
7
Blockade of astrocytic glutamate uptake in the prefrontal cortex induces anhedonia.阻断前额叶皮层星形胶质细胞的谷氨酸摄取会导致快感缺失。
Neuropsychopharmacology. 2012 Oct;37(11):2467-75. doi: 10.1038/npp.2012.105. Epub 2012 Jun 27.
8
Female early adult depression results in detrimental impacts on the behavioral performance and brain development in offspring.女性成年早期抑郁会对后代的行为表现和大脑发育产生不利影响。
CNS Neurosci Ther. 2012 Jun;18(6):461-70. doi: 10.1111/j.1755-5949.2012.00324.x.
9
Astrocyte decrease in the subgenual cingulate and callosal genu in schizophrenia.精神分裂症患者扣带回下脚和胼胝体膝部的星形胶质细胞减少。
Eur Arch Psychiatry Clin Neurosci. 2013 Feb;263(1):41-52. doi: 10.1007/s00406-012-0328-5. Epub 2012 Jun 4.
10
Chronic clomipramine treatment restores hippocampal expression of glial cell line-derived neurotrophic factor in a rat model of depression.慢性氯丙咪嗪治疗可恢复抑郁模型大鼠海马胶质细胞源性神经营养因子的表达。
J Affect Disord. 2012 Dec 10;141(2-3):367-72. doi: 10.1016/j.jad.2012.03.018. Epub 2012 Jun 1.
Zotero 插件