Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.
Biol Psychiatry. 2013 Jun 15;73(12):1172-9. doi: 10.1016/j.biopsych.2013.03.032.
Several structural and cellular changes, including marked glial anomalies, have been observed in association with major depressive disorder. Here we review these cellular alterations and highlight the importance of glial cell pathology, especially astroglial dysfunction, in the pathophysiology of neuropsychiatric disorders with a particular interest in major depressive disorder. The functional role of astrocytes in glutamate uptake and glutamate/glutamine cycling is discussed, as is the deleterious effects of chronic stress on glial cell function. Lastly, we discuss the effect of antidepressants on glial cell function and the possibility of targeting glial cells in the quest to develop novel therapeutics.
已经观察到与重度抑郁症相关的几种结构和细胞变化，包括明显的神经胶质异常。在这里，我们回顾了这些细胞变化，并强调了神经胶质细胞病理学的重要性，特别是星形胶质细胞功能障碍，在神经精神疾病的病理生理学中的重要性，特别是在重度抑郁症中。我们讨论了星形胶质细胞在谷氨酸摄取和谷氨酸/谷氨酰胺循环中的功能作用，以及慢性应激对神经胶质细胞功能的有害影响。最后，我们讨论了抗抑郁药对神经胶质细胞功能的影响，以及在寻求开发新的治疗方法时靶向神经胶质细胞的可能性。
