Merati Miesha, Woods Christi, Reznik Nina, Parker Lydia
Drs. Merati, Woods, and Parker and Ms. Reznik are with The Parker Skin and Aesthetic Clinic in Cleveland, Ohio.
J Clin Aesthet Dermatol. 2020 Nov;13(11):22-27. Epub 2020 Nov 1.
The study of the use of growth factors in conjunction with microneedling is limited. It is hypothesized that the use of human growth factors will decrease recovery time by downregulating inflammation and will continue stimulating collagen synthesis initiated by microneedling. We sought to evaluate the safety and efficacy of microneedling in combination with a novel human recombinant growth factor regenerative complex (PolyGF) for skin improvement. This study was a randomized controlled trial evaluating changes in multiple skin parameters via provider, imaging, and patient self-assessments after four microneedling treatments, each spaced one month apart, with or without a novel growth factor. Twenty female patients aged 35 to 60 years were included. Evaluation parameters included fine lines and wrinkles, evenness of skin tone, skin clarity, age spots, skin smoothness, skin firmness, and hydration of skin via dermatologic Canfield VISIA (Fairfield, New Jersey) imaging, and patient self-assessment. Significant improvement in skin texture was reported to higher degrees for the PolyGF group by VISIA imaging assessments than in the control group. Subjective assessments in skin smoothness and hydration were significantly improved in the Poly GF groups. Hydration improvements were seen to a lesser degree in the control group. Improvements in firmness and texture were seen in both the PolyGF and control groups by subjective assessment. Significantly improved subjective assessments of skin tone and melanin index were reported only in the control groups. While microneedling improved skin in several parameters, the addition of the novel growth factor to microneedling helped improve skin texture and hydration to a higher degree. Further studies are needed to characterize the effects of growth factor serum in conjunction with microneedling.
关于生长因子与微针联合使用的研究有限。据推测，使用人类生长因子将通过下调炎症反应来缩短恢复时间，并持续刺激由微针引发的胶原蛋白合成。我们旨在评估微针与一种新型人类重组生长因子再生复合物（PolyGF）联合用于改善皮肤的安全性和有效性。本研究为一项随机对照试验，通过医疗人员评估、成像以及患者自我评估，来评估在进行四次微针治疗（每次间隔一个月）后，添加或不添加新型生长因子时多种皮肤参数的变化。纳入了20名年龄在35至60岁之间的女性患者。评估参数包括细纹和皱纹、肤色均匀度、皮肤清晰度、老年斑、皮肤光滑度、皮肤紧致度以及通过皮肤科Canfield VISIA（新泽西州费尔菲尔德）成像和患者自我评估得出的皮肤水合作用。通过VISIA成像评估，PolyGF组的皮肤质地改善程度高于对照组。PolyGF组在皮肤光滑度和水合作用方面的主观评估有显著改善。对照组在水合作用方面的改善程度较小。通过主观评估，PolyGF组和对照组在紧致度和质地上均有改善。仅在对照组中，皮肤色调和黑色素指数的主观评估有显著改善。虽然微针在几个参数上改善了皮肤，但在微针治疗中添加新型生长因子有助于在更高程度上改善皮肤质地和水合作用。需要进一步研究来确定生长因子血清与微针联合使用的效果。
