Lüdtke F E, Pogrzeba B, Mandrek K, Lepsien G, Neufang T, Golenhofen K
Department of General Surgery, University of Göttingen, FRG.
Dig Dis. 1991;9(6):371-81. doi: 10.1159/000171326.
The mechanical activity of isolated muscle strips from different regions of 33 human stomachs was measured under auxotonic conditions. After application of bombesin (stepwise increases in organ bath concentrations 10(-9) to 10(-6) mol/l) the following in vitro effects were observed in human gastric muscle: (1) Bombesin stimulated both circular and longitudinal preparations from all regions of the human stomach and circular duodenum. (2) The quality of the responses to bombesin application was dependent on the general myogenic characteristics of the preparations of the different stomach regions. The contraction pattern changed at high bombesin concentrations in the organ bath to slower fluctuations. (3) Bombesin resulted in a maximal tonic response in the pyloric region preparations. An increase in tone was usually observed in the inner pyloric preparations, being typical for the region. (4) The effects of bombesin on the human stomach were stronger than the effects of many other regulatory peptides and of the reaction to acetylcholine. (5) The bombesin-induced effects were unaltered by pretreatment with atropine or TTX. (6) The response to bombesin frequently lasted for hours after washing before reassuming the original state.
在辅助等张条件下，对来自33例人胃不同区域的离体肌条的机械活动进行了测量。施加蛙皮素后（器官浴浓度从10⁻⁹逐步增加至10⁻⁶mol/L），在人胃肌中观察到以下体外效应：（1）蛙皮素刺激人胃所有区域以及十二指肠环行肌的环行和纵行肌条。（2）对施加蛙皮素的反应性质取决于不同胃区域肌条的一般肌源性特征。在器官浴中蛙皮素浓度较高时，收缩模式变为较慢的波动。（3）蛙皮素在幽门区域肌条中引起最大强直反应。通常在内侧幽门肌条中观察到张力增加，这是该区域的典型表现。（4）蛙皮素对人胃的作用强于许多其他调节肽的作用以及对乙酰胆碱的反应。（5）用阿托品或河豚毒素预处理后，蛙皮素诱导的效应未改变。（6）冲洗后，对蛙皮素的反应在恢复到原始状态之前常常持续数小时。
