Lüdtke F E, Golenhofen K, Köhne C
Department of General Surgery, University of Göttingen.
Digestion. 1988;39(4):210-8. doi: 10.1159/000199628.
For a precise analysis of the cholecystokinin (CCK 8) effects on human stomach, we dissected strips of longitudinal and circular muscle from the fundus, corpus and antrum, and circular muscle from the inner and outer pyloric sphincter and duodenum. Specimens were taken during gastrectomy and from stomachs of kidney donors. Mechanical activity was simultaneously recorded under auxotonic conditions. After CCK 8 application, the following effects were observed: (1) direct excitatory effects of CCK 8 with great regional variations in quality and intensity; (2) increases in amplitude of phasic contractions in the outer plyorus and longitudinal antrum (in the other types of preparations the effects were negligible; (3) increases in tonic activity in preparations of the proximal stomach and in strips of longitudinal muscle form the antrum, and (4) remarkable interindividual differences, with negligible responses in one third of the 24 human stomachs examined.
为了精确分析胆囊收缩素（CCK 8）对人体胃部的影响，我们从胃底、胃体和胃窦分离出纵行肌和环行肌条，以及来自幽门内、外括约肌和十二指肠的环行肌。标本取自胃切除术过程中以及肾供体的胃部。在辅助张力条件下同时记录机械活动。应用CCK 8后，观察到以下效应：（1）CCK 8的直接兴奋效应，在性质和强度上存在很大的区域差异；（2）幽门外层和胃窦纵行肌的相性收缩幅度增加（在其他类型的标本中，这种效应可忽略不计）；（3）胃近端标本和胃窦纵行肌条的紧张性活动增加；（4）个体间存在显著差异，在所检查的24个胃部中，三分之一的反应可忽略不计。
