Lüdtke F E, Lammel E, Mandrek K, Peiper H J, Golenhofen K
Department of General Surgery, University of Göttingen, FRG.
Dig Dis. 1991;9(6):414-31. doi: 10.1159/000171332.
In vitro gastric motility was investigated in 48 human and 16 canine stomachs by measuring the mechanical activity of isolated muscle strips under auxotonic conditions. For a precise regional differentiation, we recorded the mechanical activity of longitudinal and circular strips from fundus, corpus and antrum, as well as from circular preparations of the inner and outer layer of the pyloric sphincter and from the duodenum. The analysis showed that the anatomical division of the stomach into three distinct regions resulted physiologically in different patterns of contraction in vitro for each region. The fundus exhibited purely tonic spontaneous activity and a tonic contraction pattern after application of acetylcholine whereas the activity in the circular antrum was purely phasic. A combination of tonic and phasic contractions was found in the corpus and longitudinal antrum. A major difference in the basic spontaneous activity pattern was evident between man and dog. A gradient of intrinsic frequency in the stomach from proximal to distal was seen in the dog but not in man. A physiologically distinct area exists in the pyloric region of both species adjacent to the antrum and duodenum. The pyloric ring has its own spontaneous activity (minute-rhythm), reacts to the application of acetylcholine with relatively weak contractions and, unique to the dog, was delineated by histamine-induced maximal contractions. The results provide evidence that the pyloric ring is a distinct organ with specific functional characteristics in its cellular-myogenic structure.
通过测量等张条件下离体肌条的机械活性，对48例人胃和16例犬胃进行了体外胃动力研究。为了进行精确的区域区分，我们记录了来自胃底、胃体和胃窦的纵行和环行肌条，以及幽门括约肌内层和外层的环行肌条和十二指肠的机械活性。分析表明，胃在解剖学上分为三个不同区域，在生理上导致每个区域在体外有不同的收缩模式。胃底表现出纯粹的紧张性自发活动，应用乙酰胆碱后呈现紧张性收缩模式，而环行胃窦的活动则完全是相性的。在胃体和纵行胃窦中发现了紧张性和相性收缩的组合。人与犬在基本自发活动模式上存在明显差异。犬胃从近端到远端存在固有频率梯度，而人则没有。在这两个物种的幽门区域，与胃窦和十二指肠相邻处存在一个生理上不同的区域。幽门环有其自身的自发活动（分钟节律），对乙酰胆碱的应用反应为相对较弱的收缩，并且，犬独有的是，由组胺诱导的最大收缩所界定。结果提供了证据，表明幽门环是一个在细胞 - 肌源性结构上具有特定功能特征的独特器官。
