Jørgensen C S, Dall F H, Storkholm J, Jensen S L, Gregersen H
Institute of Experimental Clinical Research, University of Aarhus, Denmark.
Dig Dis. 1991;9(6):401-7. doi: 10.1159/000171330.
The aim was to investigate elastic wall properties of the isolated perfused porcine duodenum using manometry and impedance planimetry. Distension of an intraluminal balloon with definite pressure steps of 0.5, 1.0, 2.0, 3.0 and 5.0 kPa was done with simultaneous recording of balloon pressure and balloon cross-sectional area (Bcsa). Wall thickness of the relaxed intestine was estimated from measurement of tissue density. The elastic wall parameters were calculated from these measurements. Balloon inflation elicited a phase of rapid Bcsa increase followed by an accommodation phase of slow Bcsa increase. At steady state, the circumferential and the radial wall stress increased as linear functions of the applied balloon pressure, while the circumferential and the radial wall strain increased nonlinearly. The incremental elastic moduli increased exponentially. Our model allows the study of passive biomechanical wall properties of the intact duodenum. The duodenal wall showed qualitatively and also quantitatively an elastic nature.
目的是使用测压法和阻抗平面测量法研究离体灌注猪十二指肠的弹性壁特性。通过以0.5、1.0、2.0、3.0和5.0 kPa的确定压力步长对腔内球囊进行扩张，并同时记录球囊压力和球囊横截面积（Bcsa）。通过测量组织密度来估计松弛肠段的壁厚。根据这些测量结果计算弹性壁参数。球囊充气引发了Bcsa快速增加的阶段，随后是Bcsa缓慢增加的适应阶段。在稳态下，周向和径向壁应力随施加的球囊压力呈线性函数增加，而周向和径向壁应变呈非线性增加。增量弹性模量呈指数增加。我们的模型允许研究完整十二指肠的被动生物力学壁特性。十二指肠壁在定性和定量上均表现出弹性性质。
