Gregersen H, Kraglund K, Djurhuus J C
Institute of Experimental Clinical Research, University of Aarhus, Denmark.
Am J Physiol. 1990 Jul;259(1 Pt 1):G26-31. doi: 10.1152/ajpgi.1990.259.1.G26.
A probe for measurement of intestinal cross-sectional area (CA) was used to elucidate variations of human gut CA during the interdigestive migrating motility complex (MMC). A balloon was inflated by saline at a pressure of 1 kPa, and variations of balloon CA (BCSA) were measured by means of the field-gradient principle. Duodenal phasic activity was measured by perfused side holes proximal to, distal to, and inside the balloon. In vitro characterization of probe performance showed that static measurement of BCSA was very accurate regardless of the configuration of the balloon. However, during dynamic measurements, BCSA was valid only for slow variations in BCSA due to resistance in the evacuation and inflation system. Eight duodenal MMCs were recorded. BCSA increased consistently from the start of phase I to the end of phase II from 72 (45-100) to 136 (87-154) mm2. During late phase II, a large BCSA increase was recorded. A positive correlation between the phasic activity level in phases I and II of MMC and maximal BCSA in duodenum was demonstrated (proximal P less than 0.01; distal P less than 0.05). BCSA during phase III was small but could not be estimated accurately because steady-state conditions were not obtained. The large BCSA in late phase II suggests a relaxation of the duodenal wall secondary to a decrease in smooth muscle tone. The results add evidence to previous findings of a low-resistance or large-capacitance situation in late phase II, observed as a large pancreaticobiliary excretion into the duodenum and an increased flow of duodenal contents.
使用一种用于测量肠道横截面积（CA）的探头来阐明人体肠道CA在消化间期移行性运动复合波（MMC）期间的变化。通过在1 kPa的压力下用盐水使球囊膨胀，并利用场梯度原理测量球囊横截面积（BCSA）的变化。通过在球囊近端、远端和内部的灌注侧孔测量十二指肠的阶段性活动。探头性能的体外表征表明，无论球囊的构型如何，BCSA的静态测量都非常准确。然而，在动态测量期间，由于排空和充气系统中的阻力，BCSA仅对BCSA的缓慢变化有效。记录了8个十二指肠MMC。从I期开始到II期结束，BCSA持续增加，从72（45 - 100）mm²增加到136（87 - 154）mm²。在II期后期，记录到BCSA大幅增加。MMC的I期和II期的阶段性活动水平与十二指肠中的最大BCSA之间存在正相关（近端P < 0.01；远端P < 0.05）。III期的BCSA较小，但由于未获得稳态条件，无法准确估计。II期后期的大BCSA表明十二指肠壁因平滑肌张力降低而松弛。这些结果为先前在II期后期观察到的低阻力或大容量情况的发现增加了证据，表现为大量胰胆排泄到十二指肠以及十二指肠内容物流量增加。
