Rose Adam J, Berlowitz Dan R, Orner Michelle B, Kressin Nancy R
Center for Health Quality, Outcomes, and Economic Research, Bedford VA Medical Center, Bedford, MA 01730, USA.
J Clin Hypertens (Greenwich). 2007 Dec;9(12):937-43. doi: 10.1111/j.1524-6175.2007.07332.x.
The relative contributions of adherence and treatment intensity to blood pressure (BP) control are not well understood. The authors studied patients with uncontrolled hypertension (N=410) from 3 primary care clinics in the Veterans Affairs (VA) medical system. A questionnaire was used to assess patient adherence to therapy, and VA system pharmacy fills were used to assess the intensity of the antihypertensive regimen. At baseline, an inadequate antihypertensive regimen was implicated as the most probable reason for uncontrolled BP in a majority of patients (72%), while nonadherence could only be implicated in 13%. In multivariate longitudinal analyses, patients who had an increase in their medical treatment during the study had lower final diastolic BP levels compared with the patients who did not (-3.70 mm Hg; P<.05). While patient adherence to therapy plays a role, vigorous clinical management by the clinician is a more important contributor to BP control.
依从性和治疗强度对血压控制的相对贡献尚未得到充分理解。作者研究了退伍军人事务部(VA)医疗系统中3家初级保健诊所的血压未得到控制的患者(N = 410)。使用问卷调查来评估患者对治疗的依从性,并使用VA系统药房的配药情况来评估降压方案的强度。在基线时,大多数患者(72%)血压未得到控制的最可能原因被认为是降压方案不足,而不依从仅占13%。在多变量纵向分析中,与未增加治疗的患者相比,在研究期间增加药物治疗的患者最终舒张压水平更低(-3.70 mmHg;P <.05)。虽然患者对治疗的依从性起一定作用,但临床医生积极的临床管理对血压控制更为重要。