Ajayi A A, Akinleye A O, Udoh S J, Ajayi O O, Oyelese O, Ijaware C O
Department of Medicine, Obafemi Awolowo university, Ile-Ife, Nigeria.
Eur J Clin Pharmacol. 1991;41(4):383-5. doi: 10.1007/BF00314973.
Chloroquine chemotherapy of malaria fever induces severe generalised pruritus in a large proportion of black Africans. In a double blind, placebo controlled, randomised, parallel group study in 28 historically chloroquine pruritus-reactor (R+) patients, with malaria, we evaluated the prophylactic and the palliative antipruritic actions of prednisolone (5 mg) or niacin (50 mg). There was a significant prophylactic effect of both drugs on the pruritogenecity of chloroquine as well as significant reduction in the area under the pruritus intensity-time curve, AUC(0-72 h) by niacin. The salutary effect both of niacin and prednisolone on chloroquine pruritogenecity resulted neither, in the mitigation of malaria parasite clearance, nor in the clinical amelioration following antimalaria therapy.
氯喹治疗疟疾发热会在很大比例的非洲黑人中引发严重的全身性瘙痒。在一项针对28名既往有氯喹瘙痒反应（R+）的疟疾患者的双盲、安慰剂对照、随机平行组研究中，我们评估了泼尼松龙（5毫克）或烟酸（50毫克）的预防性和缓解性止痒作用。两种药物对氯喹的致痒性均有显著的预防作用，并且烟酸使瘙痒强度-时间曲线下面积AUC(0 - 72小时)显著降低。烟酸和泼尼松龙对氯喹致痒性的有益作用既未减轻疟原虫清除，也未改善抗疟治疗后的临床症状。
