Lapin I P
Farmakol Toksikol. 1985 Jul-Aug;48(4):50-4.
The derivatives of GABA and beta-phenylethylamine (PEA) the tranquilizer phenibut and muscle relaxant baclofen (p-chloro-beta-phenyl-GABA, lioresal) diminished all studied effect of PEA in mice, namely seizures, sedation, excitation, hyperthermia. Diazepam diminished only seizures whereas haloperidol excitation and hyperthermia. PEA injections anatogonized (the sedative and hypothermic effects of phenibut and diazepam and the anticonvulsant (against l-kynurenine) effect of phenibut and baclofen. The role of antagonism to PEA in the mechanism of the antianxiety effect of tranquilizers is discussed.
γ-氨基丁酸（GABA）和β-苯乙胺（PEA）的衍生物——镇静剂苯丁胺和肌肉松弛剂巴氯芬（对氯-β-苯基-GABA，力奥来素）减弱了PEA对小鼠的所有研究效应，即癫痫发作、镇静、兴奋、体温过高。地西泮仅减弱癫痫发作，而氟哌啶醇减弱兴奋和体温过高。注射PEA拮抗了苯丁胺和地西泮的镇静和体温过低效应以及苯丁胺和巴氯芬的抗惊厥（针对L-犬尿氨酸）效应。讨论了对PEA的拮抗作用在镇静剂抗焦虑作用机制中的作用。
