Cho Young-Ho, Youn Sechan, Lee Dong Woo
Digital Nanolocomotion Center, Department of BioSystems, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Republic of Korea.
J Nanosci Nanotechnol. 2007 Nov;7(11):4214-9.
The paper presents a couple of biofluidic devices, whose functions are inspired from biological cell concentration and deformability monitoring functions. The cell concentration monitoring chip is inspired from RBC control mechanism in kidney, performing cell concentration monitoring functions. The cell deformability chip, inspired from selective RBC destruction mechanism in spleen, performs mechanical cell deformability monitoring functions. The structures and principles of the bio-inspired chips are presented and compared with those of the biological organs. The unique features and performance characteristics of the bio-inspired chips are analyzed and verified from experimental study. The bio-inspired cell concentration monitoring chips perform flow-rate insensitive concentration measurement, while the bio-inspired cell deformability monitoring chips achieve size-independent cell deformability measurement. Common advantages of the bio-inspired chips include simple structures, digital signals and high integrability, thus making them suitable for use in integrated digital biomedical systems.
本文介绍了几种生物流体装置，其功能源自生物细胞浓度和可变形性监测功能。细胞浓度监测芯片的灵感来自肾脏中的红细胞控制机制，执行细胞浓度监测功能。细胞可变形性芯片的灵感来自脾脏中的选择性红细胞破坏机制，执行细胞机械可变形性监测功能。介绍了这些受生物启发的芯片的结构和原理，并与生物器官的结构和原理进行了比较。通过实验研究分析并验证了受生物启发的芯片的独特特性和性能特征。受生物启发的细胞浓度监测芯片可进行与流速无关的浓度测量，而受生物启发的细胞可变形性监测芯片可实现与尺寸无关的细胞可变形性测量。受生物启发的芯片的共同优点包括结构简单、数字信号和高集成度，因此使其适用于集成数字生物医学系统。
