Ring enlargement of cyclic acetals and ketals: a way to seven-membered nucleoside phostones.
作者信息
Páv Ondrej, Barvík Ivan, Budesínský Milos, Masojídková Milena, Rosenberg Ivan
机构信息
Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo n. 2, 166 10 Prague 6, Czech Republic.
出版信息
Org Lett. 2007 Dec 20;9(26):5469-72. doi: 10.1021/ol7023899. Epub 2007 Nov 30.
PMID:18047360
Abstract
Novel seven-membered nucleoside phostones were prepared by the reaction of chlorodiethyl phosphite with 3',5'-acetals or ketals derived from xylo-dT. A mechanism for the ring enlargement was proposed, and support for it was provided by ab initio calculations.
摘要
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