Hoppe Christian, Elger Christian E, Helmstaedter Christoph
Department of Epileptology, University of Bonn Medical Centre, Bonn, Germany.
Epilepsia. 2007;48 Suppl 9:26-9. doi: 10.1111/j.1528-1167.2007.01397.x.
In temporal lobe epilepsy, long-term memory disturbance starts early in life mainly affecting declarative memory. Primary impairment of episodic memory often results in reduced semantic and autobiographic memory. Neuropsychological performance predicts academic achievement and everyday life functioning while subjective memory complaints are highly correlated with depression. Memory impairment is also influenced by initial brain damage, developmental retardation and dynamic factors (e.g., seizure frequency, medication). Damage of functional tissue, low mental reserve capacity, and poor seizure outcome increase the risk for postsurgical memory impairment whereas functional release due to seizure freedom counteracts negative impact. Preliminary findings indicate that postsurgical training improves memory deficits and encourage further research.
在颞叶癫痫中，长期记忆障碍在生命早期就开始出现，主要影响陈述性记忆。情景记忆的原发性损害常常导致语义记忆和自传体记忆减退。神经心理学表现可预测学业成绩和日常生活功能，而主观记忆主诉与抑郁症高度相关。记忆障碍还受到初始脑损伤、发育迟缓及动态因素（如癫痫发作频率、药物治疗）的影响。功能性组织损伤、低心理储备能力和不良的癫痫发作结果会增加术后记忆障碍的风险，而癫痫发作缓解所致的功能释放则可抵消负面影响。初步研究结果表明，术后训练可改善记忆缺陷，这鼓励了进一步的研究。
