Seideman P
Department of Internal Medicine, Karolinska Institute, Danderyd Hospital, Sweden.
J Clin Pharmacol. 1991 Sep;31(9):804-7. doi: 10.1002/j.1552-4604.1991.tb01915.x.
Paracetamol is an analgetic drug with additive effect if combined with indomethacin. In rat experiments, paracetamol has been shown to be gastro-protective, and in animal experiments, indomethacin blood levels decreased during combined treatment with paracetamol. The kinetic effect of paracetamol on indomethacin has been investigated in ten healthy volunteers. The mean area under the indomethacin plasma concentration curve AUC 0-alpha was 10.4 +/- 4.21 micrograms/mL x hr and did not change during combined paracetamol treatment (11.0 +/- 3.24 micrograms/mL x hr NS). Paracetamol levels were unchanged. In this study, no evidence was found that paracetamol can alter the pharmacokinetics of indomethacin in humans.
对乙酰氨基酚是一种镇痛药，与吲哚美辛合用时具有相加作用。在大鼠实验中，对乙酰氨基酚已被证明具有胃保护作用，在动物实验中，与对乙酰氨基酚联合治疗期间吲哚美辛的血药浓度降低。在10名健康志愿者中研究了对乙酰氨基酚对吲哚美辛的动力学影响。吲哚美辛血浆浓度曲线下的平均面积AUC 0-α为10.4±4.21微克/毫升×小时，在对乙酰氨基酚联合治疗期间没有变化（11.0±3.24微克/毫升×小时，无显著性差异）。对乙酰氨基酚的水平没有变化。在这项研究中，没有发现证据表明对乙酰氨基酚会改变吲哚美辛在人体内的药代动力学。
