Topkaya Aynur Eren, Sahin Sevki, Aksungar Fehime Benli, Boru Ulku Turk, Yildiz Zeynep, Sur Haydar
Department of Microbiology, Faculty of Medicine, Maltepe University, Istanbul, Turkey.
Med Sci Monit. 2007 Dec;13(12):CR567-9.
Multiple sclerosis (MS) is an immune-mediated inflammatory demyelinating disease of uncertain etiology. Although the mechanisms of inducting autoimmunity by some of the infectious agents have been investigated, there is not yet enough research on streptococcal infections.
MATERIAL/METHODS: To understand the effect of past group A streptococcal infection on MS, antistreptolysin O (ASO) and antideoxyribonuclease B (ADNase B) were measured in 21 patients with relapsing-remitting MS and 21 healthy blood donors by nephelometric assay.
ADNase B levels in the patients with MS were found to be significantly higher than in the controls (p<0.001); however, ASO levels were similar in both groups.
These findings indicate that a relationship between multiple sclerosis and streptococcal infections may exist, but to acquire a better understanding of the role of group A streptococci in the pathogenesis of multiple sclerosis, more studies with animal models are necessary.
多发性硬化症（MS）是一种病因不明的免疫介导的炎症性脱髓鞘疾病。尽管已经对一些感染因子引发自身免疫的机制进行了研究，但对链球菌感染的研究还不够充分。
材料/方法：为了解过去A组链球菌感染对MS的影响，通过散射比浊法对21例复发缓解型MS患者和21名健康献血者测定抗链球菌溶血素O（ASO）和抗脱氧核糖核酸酶B（ADNase B）。
发现MS患者的ADNase B水平显著高于对照组（p<0.001）；然而，两组的ASO水平相似。
这些发现表明多发性硬化症与链球菌感染之间可能存在关联，但为了更好地了解A组链球菌在多发性硬化症发病机制中的作用，有必要开展更多动物模型研究。
